UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
SCHEDULE 14A INFORMATION

Proxy Statement Pursuant to Section 14(a) of the


Securities Exchange Act of 1934


(Amendment No. )

Filed by the Registrant
Filed by a Party other than the Registrant

Check the appropriate box:

Preliminary Proxy Statement
Confidential, for Use of the Commission Only (as permitted by Rule14a-6(e)(2))
Definitive Proxy Statement
Definitive Additional Materials
Soliciting Material Pursuant to §240.14a-12


Preliminary Proxy Statement

Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2))

Definitive Proxy Statement

Definitive Additional Materials

Soliciting Material Pursuant to Section 240.14a-12
Eloxx Pharmaceuticals, Inc.

(Name of Registrant as Specified In Its Charter)

(Name of Person(s) Filing Proxy Statement if Other Than the Registrant)

Payment of Filing Fee (Check the appropriate box)

No fee required.
Fee computed on table below per Exchange Act Rules14a-6(i)(1) and0-11.

Title of each class of securities to which transaction applies:

Aggregate number of securities to which transaction applies:

:


No fee required.

Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and 0-11.
(1)
Title of each class of securities to which transaction applies:
(2)
Aggregate number of securities to which transaction applies:
(3)
Per unit price or other underlying value of transaction computed pursuant to Exchange Act Rule0-11 (Set forth the amount on which the filing fee is calculated and state how it was determined):

Proposed maximum aggregate value of transaction:

Total fee paid:

Fee paid previously with preliminary materials.
Check box if any part of the fee is offset as provided by Exchange Act Rule0-11(a)(2) and identify the filing for which the offsetting fee was paid previously. Identify the previous filing by registration statement number, or the Form or Schedule and the date of its filing.

Amount Previously Paid:

Form, Schedule or Registration Statement No.:

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Date Filed:


LOGO

April 16, 2018

To our stockholders:

On December 19, 2017, Sevion Therapeutics, Inc. (“Sevion”) acquired Eloxx Pharmaceuticals, Limited (“Private Eloxx”) pursuant to a merger betweenExchange Act Rule 0-11 (set forth the companies (the “Transaction”). Upon consummationamount on which the filing fee is calculated and state how it was determined):

(4)
Proposed maximum aggregate value of transaction:
(5)
Total fee paid:

Fee paid previously with preliminary materials.

Check box if any part of the Transaction (the “Closing”), Sevion adoptedfee is offset as provided by Exchange Act Rule��0-11(a)(2) and identify the business planfiling for which the offsetting fee was paid previously. Identify the previous filing by registration statement number, or the Form or Schedule and the date of Private Eloxx and discontinued the pursuit of Sevion’s business planpre-Closing. In connection with the Transaction, Sevion acquired allits filing.
(1)
Amount Previously Paid:
(2)
Form, Schedule or Registration Statement No.:
(3)
Filing Party:
(4)
Date Filed:

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950 Winter Street
Waltham, MA 02451
April 5, 2019
Dear Stockholders:
On behalf of the outstanding capital stockBoard of Private Eloxx in exchange for the issuance of an aggregate 20,316,656 shares of Sevion’s common stock, par value $0.01 per share (the “Common Stock”), after giving effect to a1-for-20 reverse split effected immediately prior to the Transaction. As a result of the Transaction, Private Eloxx became awholly-owned subsidiary of Sevion. While Sevion was the legal acquirer in the transaction, Private Eloxx was deemed the accounting acquirer. Immediately after giving effect to the Transaction, on December 19, 2017, Sevion changed its name to Eloxx Pharmaceuticals, Inc.

WeDirectors, you are pleased to invite youcordially invited to attend the 20182019 Annual Meeting of Stockholders (the “Annual Meeting”) of Eloxx Pharmaceuticals, Inc. to(the “Company”). The Annual Meeting will be held on Wednesday, May 16, 201829, 2019, at 2:1:00 p.m. Tel Aviv timeEastern Time at the offices of the Company, Center Entrance Learning Center, 950 Winter Street, 1st Floor, Waltham, Massachusetts 02451. The Ritz Carlton, Herzliya, located at 4 Hashunit Street, Herzliya, 4655504 Israel.

Details regarding admission to theformal Notice of Annual Meeting andis set forth in the businessenclosed material.

The matters expected to be conductedacted upon at the Annual Meeting are described in the attached proxy statement. During the Annual Meeting, stockholders will have the opportunity to ask questions and comment on our business operations.
We are pleased to once again offer our proxy materials over the Internet. We are mailing to our stockholders a Notice of Internet Availability of Proxy Materials instead of a paper copy of the Notice of Annual Meeting, proxy statement and proxy card. The Notice of StockholdersInternet Availability contains instructions on how to access those documents over the Internet and Proxy Statement.

Yourhow each of our stockholders can receive a paper copy of our proxy materials, if desired. By furnishing proxy materials over the Internet, we are lowering the costs and reducing the environmental impact of the Annual Meeting.

It is important that your views be represented. If you request a paper proxy card, please mark, sign and date the proxy card when received and return it promptly in the self-addressed, stamped envelope we will provide. No postage is required if this envelope is mailed in the United States. You also have the option of voting your proxy via the Internet at www.proxyvote.com or by calling toll free via a touch-tone phone at 1-800-690-6903. Proxies submitted by telephone or over the Internet must be received by 11:59 p.m. Eastern Time on May 28, 2019. Although we encourage you to complete and return a proxy prior to the Annual Meeting to ensure that your vote is important. Whether or notcounted, you plan tocan attend the Annual Meeting we hopeand cast your vote in person. If you willvote by proxy and also attend the Annual Meeting, there is no need to vote again at the Annual Meeting unless you wish to change your vote.
We appreciate your investment in the Company and urge you to cast your vote as soon as possible. You may simply complete, sign and return the enclosed proxy card, or follow the instructions below to submit your proxy over the telephone or through the internet. Please carefully review the instructions for each of your voting options described in this proxy statement.

Thank you for your ongoing support of and continued interest in Eloxx Pharmaceuticals, Inc. We look forward to seeing you at the Annual Meeting.

Sincerely,

[MISSING IMAGE: sg_robert-ward.jpg]
Robert E. Ward


Chairman of the Board of Directors
and Chief Executive Officer


ELOXX PHARMACEUTICALS, INC.

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950 Winter Street


Waltham, MassachusettsMA 02451

NOTICE OF 2019 ANNUAL MEETING OF STOCKHOLDERS

To Be Held On May 16, 2018

To the Stockholders of Eloxx Pharmaceuticals, Inc.:

NOTICE

YOUR VOTE IS HEREBY GIVEN that the 2018 Annual Meeting of Stockholders (the “Annual Meeting”) of Eloxx Pharmaceuticals, Inc., a Delaware corporation (the “Company”) will be held on Wednesday, May 16, 2018 at 2:00 p.m. Tel Aviv time at The Ritz Carlton, Herzliya, 4 Hashunit Street, Herzliya, 4655504 Israel for the following purposes:

IMPORTANT!
1.To
DATE AND TIME:Wednesday, May 29, 2019 at 1:00 p.m. Eastern Time
LOCATION:Company Headquarters
Center Entrance Learning Center
950 Winter Street, 1st Floor
Waltham, MA 02451
PURPOSES:
1.
to elect nine directors;
2.
to ratify the nine (9) nomineesappointment of Deloitte & Touche LLP as our independent registered public accounting firm for directorthe fiscal year ending December 31, 2019;
3.
to hold an advisory vote on the compensation of our 2018 named executive officers;
4.
to hold an advisory vote on the frequency of the advisory vote on the compensation of our named executive officers; and
5.
to transact such other business as may properly come before the Annual Meeting and at any adjournment or postponement thereof.
RECORD DATE:April 1, 2019
HOW TO VOTE:
Please vote via one of the methods below as soon as possible to ensure that your vote is counted
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BY INTERNET
Visit www.proxyvote.com
until May 28, 2019
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BY PHONE
Please call
1-800-690-6903 by May 28, 2019
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BY MAIL
Sign, date and return your proxy card in the accompanying proxy statement (the “Proxy Statement”)stamped envelope provided
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IN PERSON
You can vote in person at the meeting
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BY SMART DEVICE
Scan the barcode to hold office until the 2019 Annual Meeting of Stockholders.left with any smart device and follow the instructions

2.To ratify the selection by the Audit CommitteeApril 5, 2019
By order of the Board of Directors, of Kost Forer Gabbay & Kasierer (a member of Ernst & Young Global), as the independent registered public accounting firm of the Company for its fiscal year ending December 31, 2018.
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Neil S. Belloff
Executive Vice President, General Counsel and Corporate Secretary

3.To conduct any other business properly brought before the Annual Meeting.

These items of business are more fully described in the Proxy Statement accompanying this Notice.

The record date for the Annual Meeting is March 19, 2018. Only stockholders of record at the close of business on that date may vote at the Annual Meeting or any adjournment or postponement thereof.

Important Notice Regarding the Availability of Proxy Materials for the Annual Meeting to be Held on

May 16, 2018 at 2:00 p.m. Tel Aviv time at The Ritz Carlton, Herzliya, 4 Hashunit Street, Herzliya, 4655504 Israel

The Proxy Statement and Annual Report to the Stockholders are available at: www.proxypush.com/elox

By Order of the Board of Directors,

Gregory Weaver

Corporate Secretary

Boston, Massachusetts

April 16, 2018

You are cordially invited to attend the Annual Meeting in person. Whether or not you expect to attend the Annual Meeting, please vote by telephone or through the internet as instructed in these materials, or, if you receive a paper proxy card by mail, by completing and returning the proxy card mailed to you, as promptly as possible in order to ensure your representation at the Annual Meeting. Voting instructions are included in the accompanying Proxy Statement. Even if you have voted by proxy, you may still vote in person if you attend the Annual Meeting. Please note, however, that if your shares are held of record by a brokerage firm, bank or other agent and you wish to vote at the Annual Meeting, you must obtain a proxy issued in your name from that agent in order to vote your shares that are held in such agent’s name and account.


i

ELOXX PHARMACEUTICALS, INC.


950 Winter Street


Waltham, Massachusetts 02451

PROXY STATEMENT


FOR THE 20182019 ANNUAL MEETING OF STOCKHOLDERS

To Be Held on May 16, 2018

QUESTIONS AND ANSWERS ABOUT THESE PROXY MATERIALS AND VOTING

Why am I receiving these materials?

We are providing you29, 2019

General Information
This Proxy Statement is furnished in connection with these proxy materials becausethe solicitation by the Board of Directors of Eloxx Pharmaceuticals, Inc., a Delaware corporation (the “Board”“Company,” “Eloxx,” “we,” “our” or “Board“us”), of Directors”proxies to be voted at our 2019 Annual Meeting of Stockholders (the “Annual Meeting” or the “Meeting”) and at any adjournment or postponement of the Meeting. The Annual Meeting will take place on May 29, 2019, beginning at 1:00 p.m., Eastern Time, at our offices, Center Entrance Learning Center, 950 Winter Street, 1st Floor, Waltham, Massachusetts 02451. For directions, please contact the Company at (781) 577-5300.
We mailed the Notice of Internet Availability of Proxy Materials, or the Notice, on or about April 5, 2019 to all stockholders of record entitled to vote at the Annual Meeting and made available the Proxy Statement and form of proxy to stockholders on such date. The matters to be voted on at the Annual Meeting are set forth in the Notice and further described below. When we refer to our fiscal year, we mean the 12-month period ended December 31 of the stated year. Web links and addresses contained in this Proxy Statement are provided for convenience only, and the content on the referenced website does not constitute a part of this Proxy Statement.
QUESTIONS AND ANSWERS ABOUT THE ANNUAL MEETING AND VOTING
1.
Why did I receive a notice regarding the availability of proxy materials on the Internet?
We are providing access to our proxy materials over the Internet. Accordingly, we have sent you the Notice because the Board of Directors, or the Board, of the Company is soliciting your proxy to vote at the 2018 Annual Meeting, of Stockholders (the “Annual Meeting”) of Eloxx Pharmaceuticals, Inc. (the “Company”), including at any adjournments or postponements thereof,of the Annual Meeting. All stockholders will have the ability to be heldaccess the proxy materials on Wednesday, May 16, 2018 at 2:00 p.m. Tel Aviv time atthe website referred to in the Notice or request to receive a printed set of the proxy materials. The Ritz Carlton, Herzliya, 4 Hashunit Street, Herzliya, 4655504 Israel. proxy materials include the proxy statement, form of proxy, and our Annual Report on Form 10-K for the fiscal year ended December 31, 2018.
You are invited to attend the Annual Meeting to vote on the proposals described in this Proxy Statement. However, you do not need to attend the Annual Meeting to vote your shares. Instead, you may simply complete, sign and return the enclosed proxy card that may be mailed or made available to you or follow the instructions below to submit your proxy over the telephone or through the internet.

We intendInternet.

2.
I want to mail the proxy materials, including this Proxy Statement and our Annual Report on Form10-K for the year ended December 31, 2017, on or about April 16, 2018 to all stockholders of record entitled to vote atattend the Annual Meeting. As used in this Proxy Statement, references to “we,” “us,” “our,” “Eloxx” and the “Company” refer to Eloxx Pharmaceuticals, Inc. and our subsidiaries.

How doWhat procedures must I attend the Annual Meeting?

The Annual Meeting will be held on Wednesday, May 16, 2018 at 2:00 p.m. Tel Aviv time at The Ritz Carlton, Herzliya, 4 Hashunit Street, Herzliya, 4655504 Israel. Directionsfollow?

Admission to the Annual Meeting mayis limited to stockholders of record as of the close of business on April 1, 2019 and one immediate family member; one individual designated as a stockholder’s authorized proxy holder; or one representative designated in writing to present a stockholder proposal properly brought before the Annual Meeting. In each case, the individual must have proof of ownership of Eloxx common stock, as well as a valid government-issued photo identification, to be found athttp://www.ritzcarlton.com/en/hotels/middle-east/herzliya/hotel-overview/directions . Information on howadmitted to votethe Annual Meeting.
Proof of Ownership
If your shares are held in person atthe name of a broker, bank or other holder of record and you plan to attend the Annual Meeting, is discussed below.

you must present proof of your ownership of Eloxx common stock, such as a bank or brokerage account statement, to be admitted to the Annual Meeting.

1

A stockholder may appoint a representative to attend the Annual Meeting and/or vote on his/her behalf. Valid proof of appointment of a representative, such as a power of attorney or notarized letter, must be presented along with proof of ownership of Eloxx common stock from the holder, in order for your representative to be admitted to the Annual Meeting. If you have questions, contact the Company at (781) 577-5300.
3.
Who can vote at the Annual Meeting?

Only stockholders of record at the close of business on March 19, 2018April 1, 2019 will be entitled to vote at the Annual Meeting. On thisthe record date, there were 27,527,73835,945,608 shares of common stock outstanding and entitled to vote.

Stockholder of Record: Shares Registered in Your Name

If on March 19, 2018,April 1, 2019, your shares were registered directly in your name with our transfer agent, American Stock Transfer & Trust Company, LLC, then you are a stockholder of record. As a stockholder of record, you may vote in person at the Annual Meeting or vote by proxy. Whether or not you plan to attend the Annual Meeting, we urge you to fill out and return the enclosed proxy card that may be mailed or made available to you or vote by proxy over the telephone or on the internetInternet as instructed below to ensure your vote is counted.

Beneficial Owner: Shares Registered in the Name of a Broker, Bank or Bank

Agent

If on March 19, 2018,April 1, 2019, your shares were held, not in your name, but rather in an account at a brokerage firm, bank or other similar organization, then you are the beneficial owner of shares held in “street name” and these proxy materials are being forwardedmade available to you by that organization. The organization holding your account is considered

to be the stockholder of record for purposes of voting at the Annual Meeting. As a beneficial owner, you have the right to direct your broker, bank or other agent regarding how to vote the shares in your account. You are also invited to attend the Annual Meeting. However, since you are not the stockholder of record, you may not vote your shares in person at the Annual Meeting unless you request and obtain a valid proxy from your broker, bank or other agent.

4.
What am I votingbeing asked to vote on?

There are twofour matters scheduled for a vote:


Election of nine (9) directors (the “Nominees”, individually a “Nominee”) to hold office until the 20192020 Annual Meeting of Stockholders (“Proposal 1”); and


Ratification of the selection of Kost Forer GabbayDeloitte & Kasierer (a member of Ernst & Young Global)Touche LLP as our independent registered public accounting firm for the fiscal year ending December 31, 20182019 (“Proposal 2”);

Advisory approval of the compensation of our named executive officers, as disclosed in this Proxy Statement (“Proposal 3”); and

Advisory indication of the preferred frequency of advisory votes on the compensation of our named executive officers (“Proposal 4”).

5.
What if another matter is properly brought before the Annual Meeting?

The Board knows of no other matters that will be presented for consideration at the Annual Meeting. If any other matters are properly brought before the Annual Meeting, it is the intention of the persons named in the accompanying proxy to vote on those matters in accordance with their best judgment.

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6.
How do I vote?

For Proposal 1, you

You may vote “FOR” or “AGAINST” eachusing any of the Nominees, or “ABSTAIN” from voting for any Nomineefollowing methods:
By Mail
If you specify. For Proposal 2, the ratificationhave requested a paper set of the selection of Kost Forer Gabbay & Kasierer (a member of Ernst & Young Global) as our independent registered public accounting firm forproxy materials, complete, sign and date the fiscal year ending December 31, 2017, you may vote “FOR”accompanying proxy or “AGAINST”, or “ABSTAIN” from voting.

The procedures for voting are fairly simple:

Stockholder of Record: Shares Registeredinstruction card and return it in Your Name

the prepaid envelope. If you are a stockholder of record and return a signed proxy card but do not indicate your voting preferences, the persons named in the proxy card will vote the shares represented by your proxy card as recommended by the Board of Directors.

By Telephone or on the Internet
Eloxx has established telephone and Internet voting procedures for stockholders of record. These procedures are designed to authenticate your identity, to allow you to give your voting instructions and to confirm that those instructions have been properly recorded. Telephone and Internet voting facilities for stockholders of record will be available 24 hours a day until 11:59 p.m., Eastern Time, on May 28, 2019.
The availability of telephone and Internet voting for beneficial owners will depend on the voting processes of your broker, bank or other holder of record. We therefore recommend that you follow their voting instructions.
If you vote by telephone or on the Internet, you do not have to return your proxy or voting instruction card.
Telephone.   You can vote by calling the toll-free telephone number on the Notice. Easy-to-follow voice prompts will allow you to vote your shares and confirm that your instructions have been properly recorded.
Internet.   The website for Internet voting is www.proxyvote.com. As with telephone voting, you can confirm that your voting instructions have been properly recorded. If you vote on the Internet, you also can request electronic delivery of future proxy materials. You can also scan the QR Barcode below (or on your proxy card) with your smart device to access the website for Internet voting.
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In Person at the Annual Meeting
Stockholders who attend the Annual Meeting may vote in person at the Annual Meeting, vote by proxy using the enclosed proxy card, vote by proxy over the telephone, or vote by proxy through the internet. Whether or not you plan to attend the Annual Meeting, we urge you to vote by proxy to ensure your vote is counted.Meeting. You may still attendalso be represented by another person at the Annual Meeting and vote in person even if you have already voted by proxy.

To vote in person, come to the Annual Meeting and we will give youexecuting a ballot when you arrive.

To vote using theproper proxy card, simply complete, sign and date the enclosed proxy card and return it promptly in the envelope provided. If you return your signed proxy card to us before the Annual Meeting, we will vote your shares as you direct.

To vote over the telephone, dial toll-free1-866-430-8292 using a touch-tone phone and follow the recorded instructions. You will be asked to provide the Company number and control number from the enclosed proxy card. Your telephone vote must be received by 5:00 p.m. Tel Aviv time on May 15, 2018 to be counted.

To vote through the internet, go to www.proxypush.com/elox to complete an electronic proxy card. You will be asked to provide the Company number and control number from the enclosed proxy card. Your internet vote must be received by 5:00 p.m. Tel Aviv time on May 15, 2018 to be counted.

Beneficial Owner: Shares Registered in the Name of Broker or Bank

designating that person. If you are a beneficial owner of shares, registered in the name of your broker, bank or other agent, you should have received a voting instruction form with these proxy materials from that organization rather than from us. Simply complete and mail in the voting instruction form to ensure that your vote is counted. Alternatively, you may vote by telephone or over the internet as instructed by your broker or bank. To vote in person at the Annual Meeting, you must obtain a validlegal proxy from your broker, bank or other agent. Follow the instructions from your broker, bank or other agent included with these proxy materials, or contact your broker or bank to request a proxy form.

We provide internet proxy voting to allow you to vote your shares online, with procedures designed to ensure the authenticity and correctness of your proxy vote instructions. However, please be aware that you must bear any costs associated with your internet access, such as usage charges from internet access providers and telephone companies.

How many votes do I have?

On each matter to be voted upon, you have one vote for each share of common stock you own as of March 19, 2018.

If I am a stockholderholder of record and I do not vote, or if I return a proxy card or otherwise vote without giving specific voting instructions, what happens?

If you are a stockholder of record and do not vote by completing your proxy card, by telephone, through the internet or in person at the Annual Meeting, your shares will not be voted.

If you return a signed and dated proxy card or otherwise vote without marking voting selections, your shares will be voted, as applicable, “For” the election of all the Nomineespresent it to the Board and “For” ratificationinspector of the selection of Kost Forer Gabbay & Kasierer (a member of Ernst & Young Global) as our independent registered public accounting firm for the fiscal year ending December 31, 2017. If any other matter is properly presented at the Annual Meeting,election with your proxyholder (one of the individuals named on your proxy card) will vote your shares using his or her best judgment.

If I am a beneficial owner of shares held in street name and I do not provide my broker or bank with voting instructions, what happens?

If you are a beneficial owner of shares held in street name and you do not instruct your broker, bank or other agent howballot to vote your shares, your broker, bank or other agent may still be able to vote at the Annual Meeting.

Your vote is important.
Please complete your shares in its discretion. In this regard, under the rules of the New York Stock Exchange (NYSE), brokers, banks and other securities intermediaries that are subject to NYSE rules may use their discretion toproxy card or vote your “uninstructed” shares with respect to matters considered to be “routine” under NYSE rules, but not with respect to“non-routine” matters. In this regard, Proposal 1 is considered to be“non-routine” under NYSE rules meaning that your broker may not vote your shares on this proposals in the absence of your voting instructions. However, Proposal 2 is considered to be a “routine” matter under NYSE rules meaning that if you do not return voting instructions to your broker by its deadline, your shares may be voted by your broker in its discretion on Proposal 2.

If you area beneficial owner of shares held in street name, in order to ensure your shares are voted in the way you would prefer, youmust provide voting instructions to your broker, bank or other agent by the deadline provided in the materials you receive from your broker, bank or other agent.

Who is paying for this proxy solicitation?

We will pay for the entire cost of soliciting proxies. In addition to these proxy materials, our directors and employees may also solicit proxies in person, by telephone or by other means of communication. Directors and

employees will not be paid any additional compensation for soliciting proxies. We may also reimburse brokerage firms, banks and other agents for the cost of forwarding proxy materials to beneficial owners.

What does it mean if I receive more than one set of proxy materials?

If you receive more than one set of proxy materials, your shares may be registered in more than one name or in different accounts. Please follow the voting instructions on the proxy cards in the proxy materials Internet promptly
to ensure that all of your shares are voted.

vote is received timely.

3

7.
Can I change my vote after submitting my proxy?

Stockholder of Record: Shares Registered in Your Name

Yes. You can revoke your proxy at any time before the final vote at the Annual Meeting. If you are the record holder of your shares, you may revoke your proxy in any one of the following ways:


You may submit by mail another properly completed proxy card with a later date (which automatically revokes the earlier proxy).


You may grantsubmit a subsequent proxy by telephone or through the internet.Internet as described above.


You may send a timely written notice that you are revoking your earlier-dated proxy to our Corporate Secretary c/o Eloxx Pharmaceuticals, Inc. at 950 Winter Street, Waltham, Massachusetts 02451.


You may attend the Annual Meeting and vote in person.person as provided above. Simply attending the Annual Meeting will not, by itself, revoke your proxy.

Your most current proxy card or telephone or internetInternet proxy submission is the one that iswill be counted.

Beneficial Owner: Shares Registered in the Name of Broker, Bank or Bank

Other Agent

If your shares are held by your broker, bank or other agent, you should follow the instructions provided by your broker, bank or other agent.

When are stockholder proposals and director nominations due for next year’s Annual Meeting?

To be considered for inclusion in next year’s

8.
Why did I receive a “Notice of Internet Availability of Proxy Materials” but no proxy materials?
We distribute our proxy materials you must submit your proposal, in writing,to stockholders via the Internet under the “Notice and Access” approach permitted by December 18, 2018rules of the Securities and Exchange Commission (SEC). This approach conserves natural resources and reduces our cost of printing and distributing the proxy materials, while providing a convenient method of accessing the materials and voting. On or about April 5, 2019, we mailed a “Notice of Internet Availability of Proxy Materials” to our Corporate Secretary c/o Eloxx Pharmaceuticals, Inc. at 950 Winter Street Waltham, Massachusetts 02451, and you must comply with all applicable requirementsstockholders containing instructions on how to access the proxy materials on the Internet.
You may also request paper or e-mail delivery ofRule 14a-8 promulgated under the Securities Exchange Act of 1934, as amended (the “Exchange Act”).

Pursuant to our bylaws, if you wish to bring a proposalproxy materials on or before the deadline provided in the Notice by calling 1-800-579-1639, but note that it will take us at least three business days to mail or e-mail the proxy materials. You will also have the option to establish delivery preferences that will be applicable for all future mailings of proxy materials. We encourage stockholders or nominateto take advantage of the availability of the proxy materials on the Internet to help reduce the environmental impact and costs of our annual meetings. If you choose to receive future proxy materials by e-mail, you will receive an e-mail message next year with instructions containing a director atlink to those materials and a link to the 2019proxy voting website. Your election to receive proxy materials by e-mail will remain in effect until you terminate it.

9.
Can I access the proxy materials and the fiscal 2018 Annual Report on the Internet?
The Notice of Annual Meeting and Proxy Statement and the fiscal 2018 Annual Report are available on our website at www.eloxxpharma.com. Instead of Stockholders, but you are not requestingreceiving future proxy statements and accompanying materials by mail, most stockholders can elect to receive an e-mail that will provide electronic links to them. Opting to access your proposal or nomination be included in next year’s proxy materials you must notify our Corporate Secretary, in writing, not later thanonline will conserve natural resources, will save us the closecost of business on February 15, 2019 nor earlier than the close of business on January 16, 2019. You are also advisedreproducing documents and mailing them to review our bylaws, which contain additional requirements about advance notice of stockholder proposals and director nominations.

How are votes counted?

Votes will be counted by the inspector of election appointed for the Annual Meeting, who will separately count, for Proposal 1, with respect to each Nominee, votes “FOR,” “AGAINST,” and “ABSTAIN,” and for Proposal 2, votes ““FOR,” “AGAINST,” and “ABSTAIN.” Brokernon-votes have no effectyou, and will not be counted towardsgive you an electronic link directly to the vote total for any proposal.

proxy voting site.

What are “brokernon-votes”?

As discussed above, when a beneficial ownerStockholders of shares held in “street name” does not give voting instructions to his or her broker, bank or other securities intermediary holding his or her shares as to how toRecord:   If you vote on matters deemedthe Internet at www.proxyvote.com, simply follow the prompts to beenroll in the electronic proxy delivery service.

4

“non-routine”Beneficial Owners:   under NYSE rules,You also may be able to receive copies of these documents electronically. Please check the broker, bank or other such agent cannot voteinformation provided in the shares. These unvoted shares are counted as “brokernon-votes.” Proposal 1 is consideredproxy materials sent to be“non-routine” under NYSE rules and we therefore expect brokernon-votes to exist in connection with this proposal. Proposal 2 is considered to be a “routine” matter under NYSE rules. Accordingly, if you hold your shares in street name and do not provide voting instructions toby your broker, bank or other agent that holds your shares, yourregarding the availability of this service.
10.
What is a broker bank or other agent

As a reminder, ifnon-vote?

If you are a beneficial owner ofwhose shares are held in “street name” — that is shares held in street name, in orderof record by a broker — you must instruct the broker how to ensurevote your shares are voted in the wayshares. If you would prefer, youmustdo not provide voting instructions, your shares will not be voted on any proposal on which the broker does not have discretionary authority to vote, which are generally considered “non-routine” matters under applicable stock exchange rules. This is called a “broker non-vote.” In these cases, the broker can register your broker, bank or other agent by the deadline provided in the materials you receive from your broker, bank or other agent.

How many votes are needed to approve each proposal?

The following table summarizes the minimum vote needed to approve each proposal and the effect of abstentions and brokernon-votes.

Proposal

Number

Proposal DescriptionVote Required for ApprovalEffect of
Abstentions
Effect of
Broker
Non-
Votes
1Election of DirectorsEach Nominee receiving more “FOR” votes than “AGAINST” votesNo effectNo effect
2Ratification of the Selection of Kost Forer Gabbay & Kasierer (a member of Ernst & Young Global) as our Independent Registered Public Accounting FirmA majority of the votes cast “FOR” Proposal 2No effect

Not

Applicable

What is the quorum requirement?

A quorum of stockholders is necessary to hold a valid meeting. A quorum will be present if stockholders holding at least a majority of the outstanding shares entitled to be cast areas being present at the Annual Meeting for purposes of determining the presence of a quorum but will not be able to vote on those matters for which the beneficial owner’s authorization is required under the applicable stock exchange rules.

If you are a beneficial owner whose shares are held of record by a broker, your broker has discretionary voting authority under applicable stock exchange rules to vote your shares on the ratification of Deloitte & Touche LLP, as our independent registered public accounting firm for the fiscal year ending December 31, 2019, even if the broker does not receive voting instructions from you. However, without specific instructions from you, your broker does not have discretionary authority to vote on the election of directors, the advisory vote on 2018 executive compensation or the preferred frequency of advisory votes on executive compensation, in which case a broker non-vote will occur and your shares will not be voted on these matters.
11.
What is the quorum requirement for the Annual Meeting?
The presence of the holders of common stock representing a majority of the total votes entitled to be cast by the holders of all shares of common stock issued and outstanding, in person or represented by proxy.proxy, is necessary to constitute a quorum. Abstentions and broker non-votes are counted as present and entitled to vote for purposes of determining a quorum. On March 19, 2018,April 1, 2019, the record date, there were 27,527,73835,945,608 shares outstanding and entitled to be cast. Thus, the holders of 13,763,87017,972,805 shares must be present in person or represented by proxy at the Annual Meeting to haveconstitute a quorum.

quorum, which is necessary to transact business at the Annual Meeting.

Your shares will be counted towards the quorum only if you submit a valid proxy (or one is submitted on your behalf by your broker, bank or other nominee) or if you vote in person at the Annual Meeting. Abstentions and brokernon-votes will be counted towards the quorum requirement. If there is no quorum, the holders of a majority of shares present at the meeting in person or represented by proxy may adjourn the meeting to another date.

12.
What are the voting requirements to elect the directors and to approve each of the proposals discussed in this Proxy Statement?
ProposalVote RequiredBroker
Discretionary
Voting Allowed
Election of DirectorsMajority of Votes CastNo
Ratification of Deloitte & Touche LLPMajority of Votes CastYes
Advisory Approval of Executive CompensationMajority of Votes CastNo
Advisory Vote on Frequency of Advisory Approval of Executive
   Compensation
Majority of Votes CastNo
If you abstain from voting or there is a broker non-vote on a matter requiring a majority of the votes cast, your abstention or the broker non-vote will not affect the outcome of such vote, because abstentions and broker non-votes are not considered to be votes cast.
5

Election of Directors
Directors must be elected by a majority of the votes cast in uncontested elections, such as the election of directors at the Annual Meeting. This means that the number of votes cast “for” a director nominee must exceed the number of votes cast “against” that nominee. Abstentions and broker non-votes are not counted as votes “for” or “against” a director nominee. In a contested election, the required vote would be a plurality of votes cast.
Ratification of Deloitte & Touche LLP
The votes cast “for” must exceed the votes cast “against” to approve the ratification of Deloitte & Touche LLP as our independent registered public accounting firm. Abstentions are not counted as votes “for” or “against” this proposal.
Advisory Vote on our 2018 Named Executive Officer Compensation
The votes cast “for” must exceed the votes cast “against” to approve, on an advisory basis, the compensation of our named executive officers. Abstentions and broker non-votes are not counted as votes “for” or “against” this proposal.
Advisory Vote on Frequency of Advisory Approval of Executive Compensation
You are being asked to select one year, two years or three years based on your preference as to the frequency with which an advisory vote on executive compensation should be held. To the extent that no alternative receives a majority of the votes cast, the Board will consider the alternative receiving the greatest number of  “for” votes to be the resulting recommendation, on an advisory basis, of our stockholders. Abstentions and broker non-votes are not counted as votes for any particular frequency choice.
13.
How will my shares be voted at the Annual Meeting?
At the Meeting, the Board of Directors (through the persons named in the proxy card or, if applicable, their substitutes) will vote your shares as you instruct. If you sign a proxy card and return it without indicating how you would like to vote your shares, your shares will be voted as the Board of Directors recommends, which is:

FOR the election of each of the director nominees named in this Proxy Statement;

FOR the ratification of the appointment of Deloitte & Touche LLP as our independent registered public accounting firm for fiscal 2019;

FOR the approval, on an advisory basis, of the 2018 compensation of our named executive officers; and

FOR a frequency period of every year for future advisory stockholder votes on named executive officer compensation.
14.
Could other matters be decided at the Annual Meeting?
As of the date of this Proxy Statement, we did not know of any matters to be raised at the Annual Meeting other than those referred to in this Proxy Statement.
If you return a signed and completed proxy card or vote by telephone or on the Internet and other matters are properly presented at the Annual Meeting for consideration, the individuals named as proxies on the proxy card will have the discretion to vote for you on those matters.
6

15.
How can I find out the results of the voting at the Annual Meeting?

Preliminary voting results will be announced at the Annual Meeting. In addition, final voting results will be published in a current reportCurrent Report on Form8-K that we expect to file within four business days after the Annual Meeting. If final voting results are not available to us in time to file a Form8-K within four business days after the Annual Meeting, we intend to file a Form8-K to publish preliminary results and, within four business days after the final results are known to us, file an additional Form8-K to publish the final results.

What16.

Who will pay for the cost of the Annual Meeting and this proxy solicitation?
The Company will pay the costs associated with the Annual Meeting and solicitation of proxies, including the costs of mailing the proxy materials are availableif a written copy of such materials is requested. Our directors, officers and regular employees (who will not be specifically compensated for such services) may solicit proxies by telephone or otherwise. Arrangements will be made with brokerage houses and other custodians, nominees and fiduciaries to forward proxies and proxy materials to their principals, and we will reimburse them for their expenses. We have retained Broadridge Financial Solutions to assist in the mailing, collection and administration of proxies.
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PROPOSAL 1
ELECTION OF DIRECTORS
Nominees for Election as a Director
At the Annual Meeting, nine directors, who have been nominated by our Board of Directors, based on the internet?

The letter to stockholders,proxy statement, Form10-K and annual report tostockholders are available at www.proxypush.com/elox.

DESCRIPTION OF THE MERGER

On December 19, 2017, Sevion Therapeutics, Inc. (“Sevion”) acquired Eloxx Pharmaceuticals, Limited (“Private Eloxx” or “Eloxx Limited”) pursuant to a merger between the companies (the “Transaction”). Upon consummationrecommendation of the Transaction (the “Closing”), Sevion adopted the business plan of Private EloxxNominating and discontinued the pursuit of Sevion’s business planpre-Closing. In connection with the Transaction, Sevion acquired allCorporate Governance Committee of the outstanding capital stockBoard of Private EloxxDirectors (referred to as the Nominating Committee), are to be elected, each to hold office (subject to our By-laws) until the next annual meeting and until his or her successor has been elected and qualified. All of the nominees for director currently serve as directors and were elected by the stockholders at the 2018 Annual Meeting.

Each nominee has consented to being named as a nominee in exchangethis Proxy Statement and to serve if elected. If any nominee listed in the table below should become unavailable for any reason, which the issuanceBoard of an aggregate 20,316,656 sharesDirectors does not anticipate, the proxy will be voted for any substitute nominee or nominees who may be selected by the Board of Sevion’s common stock, par value $0.01 per share (the “Common Stock”), after giving effect to a1-for-20 reverse split effected immediatelyDirectors prior to or at the Transaction (the “Reverse Merger”). AsAnnual Meeting. Directors will be elected by an affirmative vote of a resultmajority of the Transaction, Private Eloxx became a wholly-owned subsidiaryvotes cast at the Annual Meeting in person or by proxy. There are no family relationships between any of Sevion. While Sevion wasour directors and executive officers. The information concerning the legal acquirer innominees and their security holdings has been furnished by them to us.
Our directors have been nominated by our Board of Directors, based on the transaction, Private Eloxx was deemed the accounting acquirer. Immediately after giving effect to the Transaction, on December 19, 2017, Sevion changed its name to Eloxx Pharmaceuticals, Inc.

Upon closingrecommendations of the Reverse Merger,Nominating Committee. As discussed elsewhere in this Proxy Statement, in evaluating director nominees, the Company assumedNominating Committee considers characteristics that include, among others, integrity, business experience, financial acumen, leadership abilities, familiarity with our business and businesses similar or analogous to ours, and the obligations under outstanding warrants previously issuedextent to which a candidate’s knowledge, skills, background and experience are already represented by Eloxx Limited to purchase its share capital and, in connection therewith, issued warrants to purchase 346,307 sharesother members of the Company’s common stock to certain warrant holdersour Board of Eloxx Limited.

Directors. Listed below are our director nominees with their biographies. In addition, upon closingwe have summarized for each director the reasons why such director has been chosen to serve on our Board of the Reverse Merger, the Company assumed all of the outstanding obligations under the Eloxx 2013 Share Ownership and Option Plan (the “2013 Plan”) and, accordingly, the Company has reserved 2,307,738 shares of the Company’s common stock for issuance upon the exercise of such options. As part of the Company’s assumption of the outstanding options under the 2013 Plan, the Company also assumed the 2013 Plan and accordingly reserved 189,751 shares of the Company’s common stock for future grants.

Following the Reverse Merger and reverse stock split, and commencing December 20, 2017, the Company’s Common Stock symbol on OTCQB marketplace changed to “SVOND”, and subsequently changed to “ELOX” on January 19, 2018.

Effective with the Reverse Merger, each member of the board of directors of Eloxx Limited was appointed to the Company’s Board. All members of the Boardpre-Reverse Merger, other than Steven D. Rubin, resigned from the Board. In addition, each officer of Eloxx Limited was reappointed as an officer of the Company. Also effective with the Reverse Merger, the Company’s Board affirmed its financial year end as December 31, 2017 to align with the fiscal year end of Eloxx Limited.

Directors.

PROPOSAL 1

ELECTION OF DIRECTORS

Vacancies on the Company’s Board may be filled only by persons elected by a majority of the remaining directors. A director elected by the majority of the remaining directors of the Board to fill a vacancy, in a class, including vacancies created by an increase in the number of directors, shall serve until his or her successor is duly elected and qualified, or until his or her earlier death, resignation or removal.

The Board presently has nine (9) members. Messrs. Robert Ward, Tomer Kariv, Ran Nussbaum, Gadi Veinrib, Martijn Kleijwegt and Steven Rubin, and Drs. Zafrira Avnur, Silvia Noiman and Jasbir Seehra, and all of these current directors have been nominated for reelection at the Annual Meeting by the Nominating and Corporate Governance Committee. Messrs. Ward, Kariv, Nussbaum, Veinrib and Rubin, and Drs. Avnur and Noiman were all appointed to the Board in connection with the Reverse Merger. Dr. Seehra was initially appointed to the Board by the full Board in February 2018, following recommendation of the Nominating and Corporate Governance Committee of the Board.

If elected at the Annual Meeting, all directors would serve until the 2019 Annual Meeting of Stockholders and until his or her successor has been duly elected and qualified, or, if sooner, until his or her death, resignation or removal. It is our policy to invite directors and nominees for director to attend the Annual Meeting.

If a quorum is present, each nominee receiving more votes in favor of his or her election than against, will be elected as director. Shares represented by executed proxies will be voted, if authority to do so is not withheld, for the election of the nominees named herein. Each person nominated for election has agreed to serve if elected. Our management has no reason to believe that any
Name
Age(1)
Position
Robert E. Ward61Chairman of the Board and Chief Executive Officer
Zafrira Avnur, Ph.D.68Director
Tomer Kariv58Director
Martijn Kleijwegt64Director
Silvia Noiman, Ph.D.63Director
Ran Nussbaum45Director
Steven Rubin58Director
Jasbir Seehra, Ph.D.63Director
Gadi Veinrib41Director
(1)
As of the Nominees will be unable to serve.

The brief biographies below include information, as of the date of this proxy statement, regarding the specific and particular experience, qualifications, attributes or skills that led the Nominating and Corporate Governance Committee to believe that each Nominee should serve on the Board.

Nominees for Election as a Director

The following is a brief biography of each nominee for director and a discussion of the specific experience, qualifications, attributes or skills of each nominee that led the Board, and Nominating and Corporate Governance Committee, to recommend that person as a nominee for director, as of the date of this proxy statement.

May 29, 2019.

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Mr. Robert Ward age 60, has served as Chief Executive Officer and Chairman of our Board and Chief Executive Officer since December 2017. He previously served as the Chief Executive Officer, President and member of the boardBoard of directorsDirectors at Radius Health, Inc. from December 2013 to July 2017. Prior to joining Radius, Mr. Ward was Vice President for Strategy and External Alliances for the New Opportunities iMed of AstraZeneca from 2011 to December 2013. He has held a series of progressive management and executive roles with established companies such as NPS Pharmaceuticals, Schering-Plough (Merck), Pharmacia (Pfizer), Bristol-Myers Squibb and Genentech. Mr. Ward has beenis a Director of Oncosec Medical Incorporated since November 2018 and was a Director of Akari Therapeutics, Plc since October 2016.Plc. from 2016 to 2018. Mr. Ward received a B.A. in Biology and a B.S. in Physiological Psychology, both from the University of California, Santa Barbara, aan M.S. in Management from the New Jersey Institute of Technology and an M.A. in Immunology from The Johns Hopkins University School of Medicine. Our Board believes Mr. Ward’s experience as an executive and extensive knowledge in the development of pharmaceutical products qualifies him to serve on our Board.

Dr. Noiman, age 62,Zafrira Avnur, Ph.D. has served as a member of our Board since December 2017, and previously served as a member of the board of directors of Eloxx Limited (“EloxxPharmaceuticals, Ltd. (the “Eloxx Limited Board”) since June 2017. Dr. Avnur is the Chief Scientific Officer at Quark Venture Inc., a venture investment fund focused on life sciences investments. Prior to Quark, Dr. Avnur was the Global Head of Academic Innovation, Roche Partnering from 2009 until October 2016. Dr. Avnur was also named Global Head of Neglected Diseases Roche Partnering from 2010 until 2012. She also has created nine startup companies and serves on the board of directors of several portfolio companies. Preceding her academic innovation leadership role, Dr. Avnur assumed responsibility for scientific evaluations of partnering opportunities and started the “Finder” group for Biomarkers for all therapeutic areas at Roche. She acted as Liaison between Pharma and Diagnostic Divisions and contributed to the PHC (Personalized Health Care) initiative. Prior to her partnering roles, Dr. Avnur worked in diagnostics and pharmaceuticals research and development for nearly 20 years. She held a number of positions progressing from scientist and manager to global responsibilities. In these roles she was overseeing the advancement of compounds from the bench into the clinic, and was involved in the design and execution of early clinical studies that characterize the pharmacodynamics and clinical effects of a number of compounds. Dr. Avnur received a B.Sc. in Biology and a M.Sc. in Biology from Ben Gurion University and a Ph.D. in Immunology from the Weizmann Institute of Science. Dr. Avnur also conducted post-doctoral work at Stanford Medical Center in the Cancer Immunology Department. Our Board believes Dr. Avnur’s experience as an executive in research and development qualifies her to serve on our Board.
Mr. Tomer Kariv has served as a member of our Board since December 2017, and previously served as a member of the Eloxx Limited Board since October 2016. For the past 14 years Mr. Kariv has been the Chief Executive Officer and Co-Founder of The Pontifax Group, which established five funds with over $600 million under management and invested in over 40 portfolio companies. Mr. Kariv also serves on the board of directors of many of The Pontifax Group’s portfolio companies including: V-Wave Ltd., EyeYon Medical Ltd., Cathworks Ltd., Raziel Therapeutics Ltd., VBI Vaccines Inc., LogicBio, and 89Bio Ltd. He previously served as a Director of Medical Compression Systems Ltd., Insuline Medical Ltd., Headsense Medical Ltd., Macrocure Ltd., Avraham Pharmaceuticals, Arno Therapeutics, Stimatix Ltd., Applied Immune Technologies, Allium Ltd., Tucos, Inc., Therapix Biosciences Ltd., Otic Pharma Ltd., Observer in Entera Ltd., Nutrinia Ltd., Check-Cap Ltd., and CollPlant Holdings Ltd. Mr. Kariv has 14 years of
9

experience as a seasoned venture capital industry executive and has played a key role in investing, managing and nurturing technology driven companies and startups and has held senior management positions at top Israeli financial institutions. Mr. Kariv received a B.A. in Economics from Harvard University and a Juris Doctor from Harvard Law School. Our Board believes Mr. Kariv’s extensive experience as a venture capital investor, financial executive and board member qualifies him to serve on our Board.
Mr. Martijn Kleijwegt has served as a member of our Board since December 2017, and previously served as a member of the Eloxx Limited Board since June 2017. Mr Kleijwegt is a Managing Partner and Co-Owner of Life Sciences Partners (“LSP”) since founding it in 1998. Prior to that, he also was a Partner at Euroventures Ukraine Fund and served as a General Partner at Euroventures Benelux Team. Mr. Kleijwegt has over 30 years of hands-on finance and investment experience and has gained extensive experience in the life sciences sector. He served as a Member of the Supervisory Board and as Non-Executive Director of a number of LSP portfolio companies, including Movetis, Ness, Pronota, ActoGeniX, Prosensa, Eyesense, Crucell, Asoyia, ISTO, Quadrant Plc., Rhein Biotech N.V., and QIAGEN N.V. He currently serves as a Member of the Supervisory Board, or as Non-Executive Director, of the following LSP portfolio companies: OxThera, Orphazyme, Kiadis Pharma and Pharvaris. He received a Master’s degree in Economics from Amsterdam University. Our Board believes Mr. Kleijwegt’s experience as an executive and investor in the life sciences industry qualifies him to serve on our Board.
Dr. Silvia Noiman has served as a member of our Board since December 2017 and previously served as a director of the Eloxx Limited Board since September 2013. SheDr. Noiman has over

25 years of experience as an entrepreneur and executive in the biopharmaceuticals industry, includingindustry. Currently, she is serving as venture partner ata consultant to Pontifax Venture Capital. Dr. Noiman founded Eloxx Limited in 2013 and held multiple

executive roles from October 2013 to December 2017.2017, including as Chief Executive Officer. She has served as venture partner of Pontifax IV since November 2015 and Pontifax II since 2010. Dr. Noiman founded and served as Executive Chairwoman of many of the Pontifax VC portfolio companies, including cCAM Biotherapeutics Ltd, acquired by Merck (NYSE:MRK) in 2015. She was also founder and Senior Vice President of Predix Pharmaceuticals Ltd., bringing a small early-stage drug discovery company from inception to a $500M$500 million publicly traded multi-product company (NASDAQ, EPIX).company. Under Dr. Noiman’s leadership, the companyPredix progressed four discovery programs to late stage clinical trials and formed significant big pharma partnerships. Prior to founding Predix, Pharmaceuticals Ltd., sheDr. Noiman was engaged in large-scale entrepreneurial activities in the biotech industry in Israel. Dr. Noiman received a M.P.Sc. in population genetics and hera B.Sc. in Biology from the Faculty of Life Sciences atTel-Aviv University, an M.B.A. from Recanati School of Management atTel-Aviv University, a PhDPh.D. in Molecular Biology from Tel AvivTel-Aviv University and did apost-docpost-doctoral work at the Weizmann Institute of Science. Dr. Noiman has published numerous papers and holds several patents. Our Board believes Dr. Noiman’sin-depth knowledge of the Company and her experience in executive roles in the biotechnology industry qualifies her to serve on theour Board.

Mr. Veinrib, age 40, has served as a member of our Board since December 2017, and previously served as a member of the Eloxx Limited Board since November 2014. He is a Partner atA-Grade Investments. Mr. Veinrib served as a Vice President of Elron Electronic Industries Ltd. from 2011 to July 2013. Prior to Elron, Mr. Veinrib worked at Discount Investment Corporation (DIC), serving as Assistant to the President and Chief Executive Officer of DIC. Mr. Veinrib received a B.A. in Economics from Tel Aviv University. Our Board believes Mr. Veinrib’s executive and financial leadership experience qualifies him to serve on the Board.

Mr.Ran Nussbaum age 45, has served as a member of our Board since December 2017, and previously served as a member of the Eloxx Limited Board since September 2013 He2013. Mr Nussbaum is a managing partner and theco-founderCo-Founder of The Pontifax Group.Group, which established five funds with over $600 million under management and invested in over 40 portfolio companies. Over the past 10 years, Mr. Nussbaum has been managing The Pontifax Group’s activity together with Mr. Tomer Kariv. Mr. Nussbaum is the Chairman of the Board of Keros Therapeutics Inc. From 2006 to 2008 he also served as Chief Executive Officer of Biomedix Ltd. and Spearhead Ltd., and was Chairman of the Board of Nasvax Ltd. Mr. Nussbaum’s experience in the life sciences arena coupled with over a decade of experience in the business intelligence field create a unique blend of skills, enabling him to support companies from inception to commercialization. Mr. Nussbaum currently serves as a directorDirector of UroGen Pharma Ltd. (formerly, TheraCoat), Quiet Therapeutics Ltd., Ocon Medical Ltd., N.T.B. Pharma Ltd., Lutris Pharma Ltd., Zolex Therapeutics Ltd., and Prevail Therapeutics Inc. Mr. Nussbaum also has previously served on the boards of directors of many of Pontifax’sThe Pontifax Group’s portfolio companies, including UroGencompanies: c-Cam Biotherapeutics Ltd., Prevail pharma, OconInsuline Medical ArQule Inc. and serves as Keros’ Chairman of the board. Previously, Mr. Nussbaum was a Director ofLtd., Kite Pharma, (sold to Gilead Sciences, Inc.), CcamBioBlast Pharma Ltd. (Sold to Merck & Co., CollPlant Holdings Ltd., ProTab Ltd., Fusimab Ltd. Nutrina Ltd., NovellusDx Ltd., VBI Vaccines Inc.), and Chairman of the board of NasVax, Spearhead and Biomedix.ArQule, Inc. Our Board believes Mr. Nussbaum’s experience as a venture capitalist investor in the biotechnology industry qualifies him to serve on theour Board.

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Mr. Kariv, J.D., age 57,Steven Rubin has served as a member of our Board since December 2017, and previously served as a member of the Eloxx Limited Board since October 2016. He is theCo-founder, Managing Partner and Chief Executive Officer at Pontifax Ltd. and serves as its Chairman of the board. Mr. Kariv has been the Chairman of the board of Macrocure Ltd. since November 2015 and has been a Director since March 2008. He also currently serves as a Director ofCheck-Cap Ltd. and an Independent Director of ArnoSevion Therapeutics, Inc. and VBI Vaccines Inc. He previously served as a DirectorBoard of Tucos, Inc., Therapix Biosciences Ltd. and CollPlant Holdings Ltd. Mr. Kariv has 10 years of experience as a seasoned venture capital industry executive and has played a key role in investing, managing and nurturing technology driven companies and startups and has held senior management positions at top Israeli financial institutions. Mr. Kariv received a BA in Economics from Harvard University and a Juris Doctor from Harvard Law School. Our Board believes Mr. Kariv’s extensive experience as a venture capital investor, financial executive and board member qualifies him to serve on the Board.

Mr. Rubin, age 57, has served as a member of our Board since December 2017, and previously served as a member of the Eloxx Limited BoardDirectors since May 2014. HeMr. Rubin is the Executive Vice President Administration and a Director of OPKO Health, Inc. Mr. Rubin is currently a Director of VBI Vaccines, Inc., Red Violet, Inc., Kidville, Inc.,Non-Invasive Monitoring Systems, Inc., Cocrystal Pharma, Inc., Castle Brands, Inc., Neovasc, Inc. and ChromaDex Corp. Mr. Rubin previously served as a Director of Cogint, Inc. prior to the spinoff of Red Violet from Cogint in March 2018, Dreams, Inc., Safestitch Medical, Inc. prior to its merger with TransEnterix, Inc., SciVac Therapeutics, Inc. prior to its merger with VBI Vaccines, Inc., Tiger X Medical, Inc. prior to its merger with BioCardia, Inc., and PROLOR Biotech, Inc., prior to its acquisition by OPKO Health, Inc. Mr. Rubin received a B.A. in Economics from Tulane University and a J.D. from the University of Florida. Our

Board believes Mr. Rubin’s experience in the biopharmaceutical industry, along with his extensive public company board experience qualifies him to serve on theour Board.

Dr. Avnur, Ph.D., age 67, has served as a member of our Board since December 2017, and previously served as a member of the Eloxx Limited Board since June 2017. Dr. Avnur is the Chief Scientific officer at Quark Venture Inc., a venture investment fund focused on life sciences investments. Prior to Quark, Dr. Avnur was the Global Head of Academic Innovation, Roche Partnering from 2009 until October 2016. Dr. Avnur was also named Global Head of Neglected Diseases Roche Partnering from 2010 until 2012. She also has created nine startup companies. Preceding her academic innovation leadership role, Dr. Avnur assumed responsibility for scientific evaluations of partnering opportunities and started the “Finder” group for Biomarkers for all therapeutic areas at Roche. She acted as Liaison between Pharma and Diagnostic Divisions and contributed to the PHC (Personalized Health Care) initiative. Prior to her partnering roles, Dr. Avnur worked in diagnostics and pharmaceuticals research and development for nearly 20 years. She held number positions progressing from scientist and manager to global responsibilities. In this role she was overseeing the advancement of compounds from the bench into the clinic, and was involved in the design and execution of early clinical studies that characterize the pharmacodynamics and clinical effects of a number of compounds. Dr. Avnur received a B.Sc. in biology and a M.Sc. in Biology from Ben Gurion University and a Ph.D. in Immunology from the Wizmann Institute. Our Board believes Dr. Avnur’s experience as an executive in research and development qualifies her to serve on the Board.

Mr. Kleijwegt, age 63, has served as a member of our Board since December 2017, and previously served as a member of the Eloxx Limited Board since June 2017. He is a Managing Partner andCo-owner of Life Sciences Partners (“LSP”) since founding it in 1998. Prior to that, he also was a Partner at Euroventures Ukraine Fund and served as a General Partner at Euroventures Benelux Team. Mr. Kleijwegt has over 30 years ofhands-on finance and investment experience and has gained extensive experience in the life sciences sector. He served as a Member of the Supervisory Board, or asNon-Executive Director, of a number of LSP portfolio companies, including Movetis, Ness, Pronota, ActoGeniX, Prosensa, Eyesense, Crucell, Asoyia, ISTO, Quadrant Plc., Rhein Biotech N.V., and QIAGEN N.V. He currently serves as a Member of the Supervisory Board, or asNon-Executive Director, of the following LSP portfolio companies: OxThera, Orphazyme, Kiadis Pharma and Pharvaris. He received a Master’s degree in Economics from Amsterdam University. Our Board believes Mr. Kleijwegt’s experience as an executive and investor in the life sciences industry qualifies him to serve on the Board.

Dr.Jasbir Seehra age 62, has served as a member of our Board since February 2018. HeDr. Seehra has served as CEOChief Executive Officer of Keros Therapeutics since December 2015. Before that, he worked for Third Rock Ventures and helped establish Decibel (where he still serves on their scientific advisory board)Scientific Advisory Board) and Ember Therapeutics (as chief scientific officer)Chief Scientific Officer). Before joining Ember, Dr. Seehra was part of a team of scientific advisors for many companies. He has served as an advisor on Ember’s scientific advisory boardScientific Advisory Board since the company’s launch. With greater than 25 years of experience developing innovative small molecule and biologic drugs, Dr. Seehra served as chief scientific officerChief Scientific Officer of Acceleron Pharma, Inc., which heco-founded in 2003. He has also served as vice presidentVice President of biological chemistryBiological Chemistry at Wyeth and led the small molecule lead discovery effort at Genetics Institute, Inc., where he successfully built the institute’s small molecule drug discovery capabilities, including medicinal chemistry, high throughput screening and structural biology. Dr. Seehra has authored numerous publications and is an inventor on 78 patents. Dr. Seehra received a B.S. and a Ph.D. in biochemistryBiochemistry from the University of Southampton in England. He completed his postdoctoral work at the Massachusetts Institute of Technology. Our Board believes Dr. Seehra’s drug development and executive leadership experience qualifies him to serve on our Board.

Mr. Gadi Veinrib has served as a member of our Board since 2017. Mr. Veinrib previously served as a member of the Eloxx Limited Board since November 2014. Mr. Veinrib serves as the Chairman of the Board of Aqua Maof Aquaculture Technologies Ltd., a world leader in indoor aquaculture technology, as well as other companies in the Aqua Maof Global Aquaculture Group. Mr. Veinrib serves as a board member in Israeli based Meteo-Logic Ltd. and Minute Ltd. Mr. Veinrib served as Vice President of Elron Electronic Industries Ltd., as well as a director of companies within Discount Investment Corporation Ltd. (a member of the IDB Group), including Netvision Ltd, RDSeed Ltd., Cloudyn Software Ltd. and Nana10 Ltd. Mr. Veinrib holds a B.A. in Economics from Tel Aviv University. Our Board believes Mr. Veinrib’s executive and financial leadership experience qualifies him to serve on our Board.

THE BOARD OF DIRECTORS UNANIMOUSLY RECOMMENDS
A VOTE “FOR”FOR THE NAMED NOMINEES.

ELECTION OF EACH NOMINEE UNDER PROPOSAL 1.

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INFORMATION REGARDING THE BOARD OF DIRECTORS AND CORPORATE GOVERNANCE

Independence of the Board of Directors

While the Company’s current listing exchange, the OTCQB market, does not provide any guidance in its listing standards, the Company has adopted governance standards substantially similar to the

As required under Nasdaq Stock Market (“Nasdaq”) listing rules. As required under the Nasdaq listing rules, a majority of the members of a listed company’s board of directors must qualify as “independent,” as affirmatively determined by the Company’scompany’s board. The Board consults with the Company’s counsel to ensure that the Board’s determinations are consistent with relevant securities and other laws and regulations regarding the definition of  “independent,” including those set forth in pertinent listing standards of Nasdaq, as in effect from time to time.

Consistent with these considerations, after review of all relevant identified transactions or relationships between each director, or any of his or her family members, and the Company, our senior management and our independent registered public accounting firm, the Board has affirmatively determined that the following seven directors are independent directors within the meaning of the applicable Nasdaq listing standards: Messrs. Kariv, Kleijwegt, Nussbaum, Veinrib, KleijwegtRubin and Rubin,Veinrib, and Drs. Avnur and Seehra,.Seehra. In making this determination, the Board found that none of these directors or nominees for director had a material or other disqualifying relationship with us. Mr. Ward and Dr. Noiman are not independent by virtue of their current orand prior executive officer positions.

positions, respectively, with the Company.

Board Leadership Structure

The Board has a Chairman, Mr. Ward, also our Chief Executive Officer, who has authority, among other things, to call and preside over Board meetings, to set meeting agendas and to determine materials to be distributed to the Board. Accordingly, the Chairman has substantial ability to shape the work of the Board.

The Board believes that this current structure and combination of responsibilities is optimal for the Company at this time as it will enhance the Board’s oversight by leveraging the knowledge of our Chief Executive Officer without diminishing his accountability to the full Board.

Role of the Board in Risk Oversight

One of the Board’s key functions is informed oversight of our risk management process. The Board does not have a standing risk management committee, but rather administers this oversight function directly through the Board as a whole, as well as through various Board standing committees that address risks inherent in their respective areas of oversight. In particular, our Board is responsible for monitoring and assessing strategic risk exposure, including a determination of the nature and level of risk appropriate for our Company. Our Audit Committee has the responsibility to consider and discuss our major financial risk exposures and the steps our management has taken to monitor and control these exposures, including guidelines and policies to govern the process by which risk assessment and risk management is undertaken. Our Nominating and Corporate Governance Committee monitors the effectiveness of our Corporate Governance Guidelines, including whether they are successful in preventing illegal or improper liability-creating conduct. Our Compensation Committee assesses and monitors whether any of our compensation policies and programs has the potential to encourage excessive risk-taking. The Strategic Finance Committee assists the Board in fulfilling its responsibilities to review, among other things, the Company’s long-term strategy, risks and opportunities relating to such strategy, major financial objectives and potential transactions. It is the responsibility of the chairperson of each committee of the Board to report findings regarding material risk exposures to the full Board as quickly as possible.

Meetings of the Board of Directors

After the Transaction, the

The Board met two (2)six times prior to the end of the fiscal year ending December 31, 2017. After the Transaction, each2018 and had several additional informal meetings. Each Board member attended 75% or more of the aggregate number of meetings of the Board and of the committees on which he or she served, held during the portion of the last fiscal year for which he or she was a director or committee member, except for Messrs. Kariv and Kleijwegt and Dr. Avnur.

With respect tomember. The Board also met several times during the meetingsyear on an informal basis where members received regular operational updates concerning the Company. Additional actions of the Board prior toand the Reverse Merger,committees of the Company doesBoard were adopted by written consent, which are not have records available to determine neitherincluded in the number of Boardtotal meetings held norfor the attendance of Board members.

and each committee.

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INFORMATION REGARDING COMMITTEES OF THE BOARD OF DIRECTORS

The Board has threefour committees: an Audit Committee, a Compensation Committee, and a Nominating and Corporate Governance Committee and Strategic Finance Committee. The following table provides the current committee membership information for each of the Board committees:

Name

AuditCompensationNominating
and
Corporate
Governance

Robert E. Ward

Tomer Kariv

X

Ran Nussbaum

X

Dr. Silvia Noiman, Ph.D.

Gadi Veinrib

X

Dr. Zafrira Avnur, Ph.D.

XX

Martijin Kleijwegt

X

Steven D. Rubin

X

Dr. Jasbir Seehra, Ph.D.

XX

*Committee Chairman

Below is a description of each committee of the Board.

Each of the committees has authority to engage legal counsel or other experts or consultants as it deems appropriate to carry out its responsibilities. The Board has determined that each member of each committee meets the applicable Nasdaq rules and regulations regarding “independence” and each member is free of any relationship that would impair his or her individual exercise of independent judgment with regard to the Company.

Each committee acts pursuant to a separate written charter, and each such charter has been adopted and approved by the Board of Directors. A copy of the charter of each of our committees, as well as our Corporate Governance Guidelines, are available on our website at www.eloxxpharma.com by choosing the “Investors” link and clicking on the “Corporate Governance” section.
Committee Memberships
Nominee Committee Membership(1)
NameAuditNominatingCompensationStrategic Finance
Robert E. Ward
Zafrira Avnur, Ph.D.
[MISSING IMAGE: icon-bullet.jpg]
[MISSING IMAGE: icon-chair.jpg]
Tomer Kariv
[MISSING IMAGE: icon-bullet.gif]
Martijn Kleijwegt
[MISSING IMAGE: icon-chair.jpg]
[MISSING IMAGE: icon-bullet.gif]
Silvia Noiman, Ph.D.
Ran Nussbaum
[MISSING IMAGE: icon-chair.jpg]
[MISSING IMAGE: icon-bullet.gif]
Steven Rubin
[MISSING IMAGE: icon-bullet.gif]
[MISSING IMAGE: icon-chair.gif]
Jasbir Seehra, Ph.D.
[MISSING IMAGE: icon-bullet.gif]
[MISSING IMAGE: icon-bullet.gif]
Gadi Veinrib
[MISSING IMAGE: icon-bullet.gif]
(1)As of April 1, 2019.
[MISSING IMAGE: icon-chair.jpg]
= Denotes Chair
Audit Committee

For the fiscal year ended December 31, 2017,2018, the Audit Committee was composed of three directors: Messrs. Kleijwegt and Rubin and Dr. Seehra, with Mr. Kleijwegt serving as the chairman of the committee. Dr. Seehra replaced Dr. Veinrib as a member of the Audit Committee in 2018. The Audit Committee did not meet from the time of the Transaction throughmet eight times during the fiscal year ended December 31, 2017. The Company does not have access to records to determine the number of times the Audit Committee met prior to the Reverse Merger. The Board has adopted a written Audit Committee charter that is available to stockholders on our website at http://www.eloxxpharma.com/investors/corporate-governance/.

2018. The Audit Committee of the Board was established by the Board in accordance with Section 3(a)(58)(A) of the Securities Exchange Act of 1934, as amended (the “Exchange Act”) to oversee our corporate accounting and financial reporting processes and audits of itsour financial statements. For this purpose, the Audit Committee performs several functions. The Audit Committee evaluates the performance of and assesses the qualifications of the Company’s independent registered public accounting firm; determines and approves the engagement of the independent registered public accounting firm; determines whether to retain or terminate the existing independent registered public accounting firm or to appoint and engage a new independent registered public accounting firm; reviews and approves the retention of the independent registered public accounting firm to perform any proposed permissiblenon-audit services; monitors the rotation of partners of the

13

independent registered public accounting firm on the Company’s audit engagement team as required by law; reviews and approves or disapproves transactions between the Company and any related persons; confers with management, and the Company’s independent registered public accounting firm, as appropriate, regarding the effectiveness of internal control over financial reporting; establishes procedures, as required under applicable law, for the receipt, retention and treatment of complaints received by the Company regarding accounting, internal accounting

controls or auditing matters and the confidential and anonymous submission by employees of concerns regarding questionable accounting or auditing matters; and meets to review the Company’s annual and quarterly financial statements with management and the independent registered public accounting firm, including a review of the Company’s disclosures under “Management’s Discussion and Analysis of Financial Condition and Results of Operations.”

Operations” contained in our Exchange Act reports filed with the SEC.

The Board reviews the Nasdaq listing standards definition of independence for Audit Committee members on an annual basis and has determined that all of the current members of the Audit Committee are independent (as independence is currently defined under Rule 5605(a)(2) of the Nasdaq listing rules and under Rule10A-3 under the Exchange Act). The Board has also determined that Mr. Rubin qualifies as an “audit committee financial expert,” as defined in applicable SEC rules. The Board made a qualitative assessment of Mr. Rubin’s level of knowledge and experience based on a number of factors, including his formal education and experience as a chief financialan executive officer and director for publicly and privately held companies.

Report of the Audit Committee of the Board of Directors

The Audit Committee has reviewed and discussed the audited financial statements for the fiscal year ended December 31, 20172018 with management of the Company. The Audit Committee has discussed with the independent registered public accounting firm the matters required to be discussed by Auditing Standard No. 1301,Communications with Audit Committees, as adopted by the Public Company Accounting Oversight Board (“PCAOB”). The Audit Committee has also received the written disclosures and the letter from the independent registered public accounting firm required by applicable requirements of the PCAOB regarding the independent accountants’ communications with the Audit Committee concerning independence and has discussed with the independent registered public accounting firm the accounting firm’s independence. Based on the foregoing, the Audit Committee of the Board of Directors has recommended to the Board of Directors that the audited financial statements be included in the Company’s Annual Report on Form10-K for the fiscal year ended December 31, 2017.

2018.

Respectfully submitted,

Martijn Kleijwegt


Steven D. Rubin

Dr. 
Jasbir Seehra, Ph.D.

The material in this report is not “soliciting material,” is not deemed “filed” with the SEC and is not to be incorporated by reference in any filing of the Company under the Securities Act of 1933, as amended, or the Exchange Act, whether made before or after the date hereof and irrespective of any general incorporation language in any such filing.

Compensation Committee

For the fiscal year ended December 31, 2017,2018, the Compensation Committee was composed of three directors: Mr. Veinrib and Dr.Drs. Avnur and Seehra, with Dr. Avnur serving as the chairwoman of the committee. Dr. Seehra replaced Mr. Kleijwegt as a member of the Compensation Committee in 2018. All members of our Compensation Committee are independent (as independence is currently defined in Rule 5605(a)(2) of the Nasdaq listing rules). The Compensation Committee did not meet from the time of the Transaction troughmet six times during the fiscal year ended December 31, 2017. The Company does not have access to records to determine the number of times the Compensation Committee met prior to the Reverse Merger. The Board has adopted a written Compensation Committee charter that is available to stockholders on our website at http://www.eloxxpharma.com/investors/corporate-governance/.

2018. The Compensation Committee acts on behalf of the Board to review, adopt and approve the Company’s compensation strategy, policies, plans and programs, including:


reviewing and approving corporate performance goals and objectives relevant to the compensation of our executive officers and other senior management, as appropriate;

14


reviewing and recommending to the Board the type and amount of compensation to be paid or awarded to Board members;


evaluating and approving the compensation plans and programs advisable for us,the Company, as well as evaluating and approving the modification or termination of existing plans and programs;


establishing policies with respect to equity compensation arrangements with the objective of appropriately balancing the perceived value of equity compensation and the dilutive and other costs of that compensation to us;compensation;


reviewing and approving the terms of any employment agreements, severance arrangements,change-of-control protections and any other compensatory arrangements (including, without limitation, perquisites and any other form of compensation) for our executive officers and, as appropriate, other senior management; and


administration of our equity compensation plans, pension and profit-sharing plans, stock purchase plans, bonus plans, deferred compensation plans and other similar planplans and programs.programs, if any.

Compensation Committee Processes and Procedures

The Compensation Committee holds regularly scheduled meetings and such special meetings as circumstances dictate. The agenda for each meeting is usually developed by the ChairmanChairperson of the Compensation Committee, in consultation with our Chief Executive Officer. The Compensation Committee meets regularly in executive session. However, from time to time, various members of management and other employees as well as outside advisers or consultants may be invited by the Compensation Committee to make presentations, to provide financial or other background information or advice or to otherwise participate in Compensation Committee meetings. The Chief Executive Officer may not participate in, or be present during, any deliberations or determinations of the Compensation Committee regarding his compensation. In addition, under the charter, the Compensation Committee has the authority to obtain, at our expense, advice and assistance from compensation consultants and internal and external legal, accounting or other advisers and other external resources that the Compensation Committee considers necessary or appropriate in the performance of its duties. The Compensation Committee has direct responsibility for the oversight of the work of any consultants or advisers engaged for the purpose of advising the Compensation Committee. In particular, the Compensation Committee has the authority to retain, in its discretion, compensation consultants to assist in its evaluation of executive and director compensation, including the authority to approve the consultant’s reasonable fees and other retention terms. Under the charter, the Compensation Committee may select, or receive advice from, a compensation consultant, legal counsel or other adviser to the Compensation Committee, other thanin-house legal counsel and certain other types of advisers, only after assessing the independence of such person in accordance with SEC and Nasdaq requirements that bear upon the adviser’s independence; however, there is no requirement that any adviser be independent.

The Compensation Committee considers matters related to individual compensation, such as compensation for new executive hires, as well as high-level strategic issues, such as the efficacy of our compensation strategy, potential modifications to that strategy and new trends, plans or approaches to compensation, at various meetings throughout the year. Generally, the Compensation Committee’s process comprises two related elements: the determination of compensation levels and the establishment of performance objectives for the current year. The Compensation Committee has the authority to delegate to the CEOChief Executive Officer and/or the officers of the Company who report directly to the CEOChief Executive Officer and all officers who are “insiders” subject to Section 16 of the Exchange Act (the “Senior Officers”), the determination of compensation under approved compensation programs, except that

compensation action affecting the CEOChief Executive Officer or the Senior Officers may not be delegated. The Committee has direct responsibility and power to review and approve corporate goals and objectives relevant to the compensation of the Company’s CEO,Chief Executive Officer, evaluate the performance of the CEOChief Executive Officer in light of those goals and objectives, and either as a committee or together with the other independent directors (as directed by the Board), recommend to the Board for approvalapprove the compensation level for the CEOChief Executive Officer based on this evaluation.

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Compensation Committee Consultant
The Compensation Committee has retained Radford, an Aon Hewitt Company, to which we refer as “Radford,” as its independent compensation consultant during fiscal 2018. Based on the six factors for assessing independence and identifying potential conflicts of interest that are set forth in SEC Rule 10C-1(b)(4) under the Exchange Act, the Nasdaq Listing Rules and such other factors as were deemed relevant under the circumstances, our Compensation Committee has determined that Radford is independent and the work Radford performed on behalf of the Compensation Committee did not raise any conflict of interest. Radford regularly meets with the Compensation Committee and provides advice regarding the design and implementation of our executive compensation programs, as well as our director compensation programs. In particular, Radford:

reviews and makes recommendations regarding executive and non-employee director compensation;

provides market data and performs competitive market analyses, including peer group analyses; and

assists in the preparation of certain of our compensation-related disclosures included in this Proxy Statement.
In providing its services to the Compensation Committee, with the Compensation Committee’s knowledge, Radford may contact our management from time to time to obtain data and other information from us and to work together in the development of proposals and alternatives for the Compensation Committee to review and consider. In fiscal 2018, the cost of Radford’s executive compensation and director compensation consulting services was $151,501 (exclusive of the purchase of certain Radford surveys at a cost of  $8,150).
In order to ensure that Radford is independent, Radford is engaged by, takes direction from, and reports to, only the Compensation Committee and, accordingly, only the Compensation Committee has the right to terminate or replace Radford at any time.
Compensation Committee Interlocks and Insider Participation
Each member of the Compensation Committee is an independent director within the meaning of the Nasdaq Listing Rules. There were no interlocks among any of the members of the Compensation Committee and any of our executive officers.
Nominating and Corporate Governance Committee

For the fiscal year ended December 31, 2017,2018, the Nominating and Corporate Governance Committee, or Nominating Committee, was composed of three directors: Messrs. Nussbaum and VeinribKariv and Dr. Avnur, with Mr. Nussbaum serving as the chairmanChairman of the committee.Nominating Committee. All members of the Nominating and Corporate Governance Committee are independent (as independence is currently defined in Rule 5605(a)(2) of the Nasdaq listing rules). The Nominating and Corporate Governance Committee did not meet from the time of the Transaction through the fiscal year ended December 31, 2017. The Company does not have access to records to determine the number of times the Corporate Governance Committee met prior to the Reverse Merger. The Board has adopted atwo times in 2018 (including taking action by written Nominating and Corporate Governance Committee charter that is available to stockholdersconsent on our website at http://www.eloxxpharma.com/investors/corporate-governance/one occasion).

The Nominating and Corporate Governance Committee of the Board is responsible for identifying and evaluating candidates to serve as directors of the Company (consistent with criteria approved by the Board), reviewing and evaluating incumbent directors, recommending to the Board for selection candidates for election to the Board, making recommendations to the Board regarding the membership of the committees of the Board, assessing the performance of management and the Board and developing a set of corporate governance principles for us.

the Company.

The Nominating and Corporate Governance Committee believes that candidates for director should have certain minimum qualifications and have the highest personal integrity and ethics. The Nominating and Corporate Governance Committee believes that each director should possess the requisite ability, judgment and experience to oversee the Company’s business, and should contribute to the overall diversity of the Board. Accordingly, the Nominating and Corporate Governance Committee considers the qualifications of directors and director candidates individually and in the broader context of its overall composition and the Company’s current and future needs. Candidates for director
16

nominees are reviewed in the context of the current composition of the Board, our operating requirements and the long-term interests of our stockholders. In conducting this assessment, the Nominating and Corporate Governance Committee typically considers diversity, age, skills and such other factors as it deems appropriate given the current needs of the Board and the Company, to maintain a balance of knowledge, experience and capability.

In the case of new director candidates, the Nominating and Corporate Governance Committee also determines whether the nominee is independent for Nasdaq purposes, which determination is based upon applicable Nasdaq listing standards, applicable SEC rules and regulations and the advice of counsel, if necessary. The Nominating and Corporate Governance Committee then uses its network of contacts to compile a list of potential candidates, but may also engage, if it deems appropriate, a professional search firm. The Nominating and Corporate Governance Committee conducts any appropriate and necessary inquiries into the backgrounds and qualifications of possible candidates after considering the function and needs of the Board.Board and the Company. The Nominating and Corporate Governance Committee meets to discuss and consider the candidates’ qualifications and then selects a nominee for recommendation to the Board by majority vote.

The Nominating and Corporate Governance Committee will consider director candidates recommended by stockholders. The Nominating and Corporate Governance Committee does not intend to alter the manner in which it evaluates candidates, including the minimum criteria set forth above, based on whether or not the candidate was recommended by a stockholder.

Any such stockholder recommendations must be delivered to our Corporate Secretary, together with the information required to be filed in a proxy statement with the SEC regarding director nominees, and each such nominee must consent to serve as a director if elected, no later than the deadline for submission of stockholder nominations as set forth in our By-laws and under the section of this Proxy Statement entitled “Stockholder Nominations — Advance Notice.”

Stockholder Communications with the Board of Directors

Historically, the Company has not provided a formal process related to stockholder communications with the Board. Nevertheless, every effort has been made to ensure that the views of stockholders are heard by the Board or individual directors, as applicable, and that appropriate responses are provided to shareholders in a timely manner. The Company believes its responsiveness to stockholder communications to the Board has been excellent. Nevertheless, during the upcoming year, theThe Nominating and Corporate Governance Committee will give full consideration to theconsider adoption of a formal process for stockholder communications with the Board as appropriate and, if adopted, publish it promptly and post it to the Company’s website.

Currently, communications with the Board should be made in writing and directed to the Company’s Corporate Secretary at our principal executive offices.

Code of Ethics

We have adopted the Eloxx Pharmaceuticals, Inc. Code of Business Conduct and Ethics that applies to all of our officers, directors and employees. The Code of Business Conduct and Ethics is available on our website at http://www.eloxxpharma.com/investors/corporate-governance/. If we make any substantive amendments to the Code of Business Conduct and Ethics or we grant any waiver from a provision of the Code of Business Conduct and Ethics to any executive officer or director, we will promptly disclose the nature of the amendment or waiver on our website.

Corporate Governance Guidelines

In December 2017, the Board documentedadopted our governance practices by adopting Corporate Governance Guidelines to assure that the Board will have the necessary authority and practices in place to review and evaluate our business operations as needed and to make decisions that are independent of our management. The guidelines are also intended to align the interests of directors and management with those of our stockholders. The Corporate Governance Guidelines set forth the practices the Board intends to follow with respect to Board composition and selection, Board meetings and involvement of senior management, Chief Executive Officer performance evaluation and succession planning, and Board committees and compensation. The Corporate Governance Guidelines, as well as the charters for each committee of the Board, may be viewed on our website at http://www.eloxxpharma.com/investors/corporate-governance/.

17

Stockholder Nominations — Advance Notice
Our By-laws provide that nominations for the election of directors and proposals for other business to be transacted by the stockholders may be made at an annual meeting: (a) pursuant to the Company’s notice with respect to such meeting (or any supplement thereto), (b) by or at the direction of the Board of Directors (or any duly authorized committee thereof), or (c) by any stockholder who (i) is a stockholder of record on the date of the giving of the notice and on the record date for the determination of stockholders entitled to vote at such annual meeting and (ii) complies with the notice procedures set forth in the By-laws and summarized below. The following summary is qualified in its entirety by reference to Section 1.2 of our By-laws, which contains additional information and requirements that must be adhered to.
In addition to any other applicable requirement for a nomination or proposal to be made by a stockholder, such stockholder must have given timely notice thereof in proper written form to our Corporate Secretary. To be timely, a stockholder’s notice to the Corporate Secretary must be delivered to or mailed and received at our principal executive offices not less than 90 days nor more than 120 days prior to the anniversary date of the annual meeting of the preceding year; provided that in the event that the date of the annual meeting for the current year is more than 30 days before or after the anniversary date of the prior year’s annual meeting, then on or before 10 days after the day on which the date of the current year’s annual meeting is first disclosed in a public announcement.
To be in proper written form, a stockholder’s notice to the Corporate Secretary must set forth (a) as to each person whom the stockholder proposes to nominate for election as a director: (i) all information relating to such nominee that would be required to be disclosed in solicitations of proxies for the election of such nominee as a director pursuant to Regulation 14A under the Exchange Act and such nominee’s written consent to serve as a director if elected; (ii) a description of all direct and indirect compensation and other material monetary arrangements, agreements or understandings during the past three years, and any other material relationship, if any, between or concerning such stockholder, any Stockholder Associated Person (as defined below) or any of their respective affiliates or associates, on the one hand, and the proposed nominee or any of his or her affiliates or associates, on the other hand; (iii) the class or series and number of shares of our capital stock which are owned beneficially or of record by the person; and (iv) any other information relating to the person that would be required to be disclosed in a proxy statement or other filing required to be made in connection with solicitations of proxies for election of directors pursuant to Regulation 14A of the Exchange Act; (b) as to each proposal that the stockholder seeks to bring before the meeting, a brief description of such proposal, the reasons for making the proposal at the meeting, the text of the proposal (including the text of any resolutions proposed for consideration and in the event that it includes a proposal to amend the By-laws of the Company, the language of the proposed amendment) and any material interest that the stockholder has in the proposal; and (c) as to the stockholder giving the notice: (i) the name and record address of such stockholder and any associated persons on whose behalf the nomination or proposal is made; (ii) the class or series and number of shares of our capital stock which are owned beneficially or of record by such stockholder or any associated person; (iii) a description of all arrangements or understandings between such stockholder and each proposed nominee and any other person or persons (including their names) pursuant to which the nomination(s) are to be made by such stockholder; and (iv) a representation that such stockholder is a holder of record of the Company entitled to vote at such meeting and intends to appear in person or by proxy at the annual meeting to nominate the persons named in his or her notice.
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PROPOSAL 2



RATIFICATION OF SELECTION OF
INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

The Audit Committee of the Board has selected Kost Forer GabbayDeloitte & Kasierer (a member of Ernst & Young Global)Touche LLP as our independent registered public accounting firm for the fiscal year ending December 31, 20182019 and has further directed that management submit the selection of our independent registered public accounting firm for ratification by the stockholders at the Annual Meeting. Kost Forer GabbayDeloitte & Kasierer (a member of Ernst & Young Global)Touche LLP has audited our financial statements since 2015.June 2018. Representatives of Kost Forer GabbayDeloitte & Kasierer (a member of Ernst & Young Global)Touche LLP are expected to be present at the Annual Meeting. They will have an opportunity to make a statement if they so desire and will be available to respond to appropriate questions.

Neither our bylaws,By-laws, as amended, nor other governing documents or law require stockholder ratification of the selection of Kost Forer GabbayDeloitte & Kasierer (a member of Ernst & Young Global)Touche LLP as our independent registered public accounting firm. However, the Audit Committee of the Board is submitting the selection of Kost Forer GabbayDeloitte & Kasierer (a member of Ernst & Young Global)Touche LLP to the stockholders for ratification as a matter of good corporate practice.governance. If the stockholders fail to ratify the selection, the Audit Committee of the Board will reconsider whether or not to retain that firm. Even if the selection is ratified, the Audit Committee of the Board in its discretion may direct the appointment of a different independent registered public accounting firm at any time during the year if they determine that such a change would be in the best interests of the Company and our stockholders.

The affirmative votevotes cast “for” must exceed the votes cast “against” to approve the ratification of the holders of a majority of the shares present in personDeloitte & Touche LLP as our independent registered public accounting firm. Abstentions are not counted as votes “for” or represented by proxy and entitled to vote on the matter at the Annual Meeting will be required to ratify the selection of Kost Forer Gabbay & Kasierer (a member of Ernst & Young Global).

“against” this proposal.

Principal Accountant Fees and Services

The following table represents aggregate fees billed to us for the fiscal yearsyear ended December 31, 20172018 by Deloitte & Touche LLP.
Fiscal Year Ended
December 31, 2018(1)
Audit Fees(2)
$467,358
Audit-Related Fees(3)
45,320
All Other Fees(4)
3,790
Total Fees$516,498
(1)
Includes fees billed by Deloitte & Touche LLP since their engagement on June 18, 2018.
(2)
Represents fees billed for professional services provided to us in connection with the integrated annual audit of our consolidated financial statements and 2016the effectiveness of our internal control over financial reporting, the review of our quarterly condensed consolidated financial statements, as well as audit services that are normally provided by Kost Forer Gabbay & Kasierer (a member of Ernst & Young Global)an independent registered public accounting firm in connection with statutory and regulatory filings.
(3)
Represents fees billed for professional services provided to us in connection with registration statement filings.
(4)
Represents fees billed for professional services related to annual software subscription.
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All such services and fees were pre-approved by RSM US LLP.

   Fiscal Year Ended December 31, 
   2017   2016 

Audit Fees(1)

  $      259,815   $      155,793 

Audit-Related Fees

    

Tax Fees(2)

   10,000    2,000 

All Other Fees(3)

   278,525   
  

 

 

   

 

 

 

Total Fees

  $548,340   $157,793 

(1)Represents fees billed for professional services provided to us in connection with the annual audit of our consolidated financial statements, the review of our quarterly condensed consolidated financial statements, as well as audit services that are normally provided by an independent registered public accounting firm in connection with statutory and regulatory filings or engagements for those fiscal years.
(2)Represents fees billed for tax compliance, tax advice and tax planning services, including the review and preparation of Israeli income tax returns.
(3)Represents fees billed for professional services rendered for due diligence related to the reverse merger and related SEC filings.

The Company does not have adequate records to determine if all fees described above werepre-approved by the Audit Committee.

Pre-Approval Policies in accordance with the “Pre-Approval Policy and Procedures” described below.

Pre-Approval Policy and Procedures

The Audit Committee has adopted a policy and procedures for thepre-approval of audit andnon-audit services rendered by our independent registered public accounting firm, Kost Forer Gabbay & Kasierer (a member of

Ernst & Young Global).firm. The policy generallypre-approves specified services in the defined categories of audit services, audit-related services and tax services up to specified amounts.Pre-approval may also be given as part of the Audit Committee’s approval of the scope of the engagement of the independent registered public accounting firm or on an individual, explicit,case-by-case basis before the independent registered public accounting firm is engaged to provide each service. Thepre-approval of services may be delegated to one or more of the Audit Committee’s members, but the decision must be reported to the full Audit Committee at its next scheduled meeting.

Change in Independent Registered Public Accounting Firm
On June 18, 2018, the Audit Committee approved the dismissal of Kost Forer Gabbay & Kaiserer, a Member of Ernst & Young Global (“EY”), as the Company’s independent registered public accounting firm, and approved the appointment of Deloitte & Touche LLP (“Deloitte & Touche”) as the Company’s independent registered public accounting firm to audit the Company’s financial statements for the fiscal year ending December 31, 2018.
The reports of EY on the Company’s consolidated financial statements for the fiscal years ended December 31, 2017 and 2016 did not contain an adverse opinion or a disclaimer of opinion, and were not qualified or modified as to uncertainty, audit scope, or accounting principle.
During the fiscal years ended December 31, 2017 and 2016 and the subsequent interim period through June 18, 2018, there were (i) no disagreements (as defined in Item 304(a)(1)(iv) of Regulation S-K) with EY on any matter of accounting principles or practices, financial statement disclosure, or auditing scope or procedure, which disagreements, if not resolved to the satisfaction of EY, would have caused EY to make reference thereto in their reports on the Company’s financial statements, and (ii) no “reportable events” (as defined in Item 304(a)(1)(v) of Regulation S-K).
During the fiscal years ended December 31, 2017 and 2016 and the subsequent interim periods preceding the dismissal of EY, the Company did not consult with Deloitte & Touche regarding either (i) the application of accounting principles to a specified transaction, either completed or proposed; or the type of audit opinion that might be rendered on the Company’s financial statements, and neither a written report or oral advice was provided to the Company that Deloitte & Touche concluded was an important factor considered by the Company in reaching a decision as to the accounting, auditing or financial reporting issue; or (ii) any matter that was the subject of a “disagreement” (as described in Item 304(a)(1)(iv) of Regulation S-K) or a “reportable event” (as described in Item 304(a)(1)(v) of Regulation S-K).
THE BOARD OF DIRECTORS UNANIMOUSLY RECOMMENDS
A VOTE “FOR”FOR PROPOSAL 2.

20

PROPOSAL 3
ADVISORY VOTE ON EXECUTIVE COMPENSATION
The Board recognizes the interests our investors have in the compensation of our named executive officers. In recognition of that interest and as required by the Dodd-Frank Wall Street Reform and Consumer Protection Act (the “Dodd-Frank Act”) and Regulation 14A of the Exchange Act, we are providing our stockholders with the opportunity to vote to approve, on an advisory basis, the compensation of our named executive officers as disclosed in this Proxy Statement in accordance with SEC rules. In accordance with that policy, the Company is asking the shareholders to approve, on an advisory basis, the compensation of the Company’s named executive officers as disclosed in this Proxy Statement.
This vote is not intended to address any specific item of compensation, but rather the overall compensation of the Company’s named executive officers and the philosophy, policies and practices described in this Proxy Statement. The compensation of the Company’s named executive officers subject to the vote is disclosed in the compensation tables and the related narrative disclosure contained in this Proxy Statement. The Company believes that its compensation policies and decisions are focused on pay-for-performance principles and strongly aligned with our stockholders’ interests. Our equity compensation (which is awarded in the form of stock options, restricted stock units and performance stock units) is designed to build executive ownership and align financial incentives focused on the achievement of our long-term strategic goals (both financial and non-financial). Compensation of the Company’s named executive officers is also designed to enable the Company to attract and retain talented and experienced executives to lead the Company successfully in a competitive environment and promote the creation of long-term stockholder value.
Accordingly, the Board is asking our stockholders to indicate their support for the compensation of our named executive officers as described in this Proxy Statement by casting a non-binding advisory vote “FOR” Proposal 3.
If a quorum is present, the votes cast “for” must exceed the votes cast “against” to approve, on an advisory basis, the compensation of our named executive officers. Abstentions and broker non-votes are not counted as votes “for” or “against” this proposal.
Because the vote is advisory, the result will not be binding on the Board or Compensation Committee. Nevertheless, the views expressed by our stockholders, whether through this say-on-pay vote or otherwise, are important to management and the Board and, accordingly, the Board and the Compensation Committee intend to consider the results of this vote in making determinations in the future regarding executive compensation arrangements.
THE BOARD OF DIRECTORS UNANIMOUSLY RECOMMENDS
A VOTE “FOR” PROPOSAL 3.
21

PROPOSAL 4
ADVISORY VOTE ON THE FREQUENCY OF SOLICITATION OF
ADVISORY STOCKHOLDER APPROVAL OF EXECUTIVE COMPENSATION
As described in Proposal 3 above, the Company’s stockholders are being provided the opportunity to cast an advisory vote on the compensation of the Company’s named executive officers. The advisory vote on executive compensation described in Proposal 3 above is referred to as a “say-on-pay vote.”
The Dodd-Frank Act and Regulation 14A of the Exchange Act also enable our stockholders, at least once every six years, to indicate their preference regarding how frequently we should solicit a non-binding advisory say-on-pay vote in our proxy materials for future annual meetings.
Under this Proposal 4, stockholders may vote to have the say-on-pay vote every year, every two years or every three years, or may abstain from voting on this matter. In voting on this proposal, you should mark your proxy for one year, two years or three years based on your preference as to the frequency with which an advisory vote on executive compensation should be held. If you have no preference you should abstain.
After careful consideration, the Board of Directors believes that the frequency of the stockholder vote on the compensation of the Company’s named executive officers should be once every year as the Board of Directors believes that stockholders should have the opportunity to determine whether executive compensation has been properly designed and measured against performance each and every year. This is consistent with our overall executive compensation philosophy which links pay primarily to the achievement of financial and strategic corporate performance objectives that are directly related to the achievement of both short-term and long-term strategic business objectives.
While the Board of Directors recommends an annual vote, stockholders are not voting to approve or disapprove of the Board of Directors’ recommendation. Rather, stockholders may cast a vote on the preferred voting frequency by selecting the option of one year, two years, three years or abstain, when voting. The option that receives the majority of votes cast by stockholders will be considered the advisory vote of the stockholders. To the extent there is any significant vote in favor of one frequency over the other options, even if less than a majority of the votes cast, our Board will consider the stockholders’ concerns and evaluate any appropriate next steps.
Although as an advisory vote this proposal is not binding on the Company or the Board, the Board values the opinions that our stockholders express through their votes and will carefully consider the stockholder vote, even if none of the options obtains a majority vote, along with all other views expressed by our stockholders, when considering how frequently we should hold the say-on-pay vote. The Board may decide that it is in the best interests of the stockholders and the Company to hold an advisory vote on executive compensation more or less frequently than the option that receives the highest number of votes by our stockholders.
THE BOARD OF DIRECTORS UNANIMOUSLY RECOMMENDS
A VOTE IN FAVOR OF “ONE YEAR” FOR PROPOSAL 4.
22

EXECUTIVE OFFICERS

The following table sets forth information concerning our executive officers as of the date of this proxy statement.

Proxy Statement.
Name

Name

Age(1)

Title

Robert E. Ward61Chief Executive Officer Directorand Chairman of the Board of Directors
Gregory Weaver63Chief Financial Officer
Dr. Pedro Huertas, MD,Gregory Williams, Ph.D.60Chief MedicalOperating Officer
David P. Snow57Chief Business Officer
Neil S. Belloff59Executive Vice President, General Counsel and Corporate Secretary

(1)
As of May 29, 2019
Mr. Robert E. Ward age 60, has served asis our Chief Executive Officer and Chairman of ourthe Board since December 2017. He previously served as the Chief Executive Officer, President and member of the boardDirectors. See “Proposal 1 — Election of directors at Radius Health, Inc. from December 2013 to July 2017. Prior to joining Radius, Mr. Ward was Vice PresidentDirectors” for Strategy and External Alliances for the New Opportunities iMeda discussion of AstraZeneca from 2011 to December 2013. He has held a series of progressive management and executive roles with established companies such as NPS Pharmaceuticals, Schering-Plough (Merck), Pharmacia (Pfizer), Bristol-Myers Squibb and Genentech. Mr. Ward has been a Director of Akari Therapeutics, Plc since October 2016. Mr. Ward received a B.A. in Biology and a B.S. in Physiological Psychology, both from the University of California, Santa Barbara, a M.S. in Management from the New Jersey Institute of Technology and an M.A. in Immunology from The Johns Hopkins University School of Medicine. Our Board believes Mr. Ward’s experience as an executive and extensive knowledge in the development of pharmaceutical products qualifies him to serve on our Board.

business experience.

Mr. Gregory Weaver age 62, has served as our Chief Financial Officer since December 2017, and was previously the Chief Financial Officer of Private Eloxx Limited beginning in October 2017. Prior to that, Mr. Weaver served as Chief Financial Officer of Prometic Life Sciences from October 2015 until August 2017, where he led the Company’s global financial team. Previously, Mr. Weaver served as Executive Vice President and Chief Financial Officer of Oryzon Genomics from September 2014 until October 2015, where he managed the company’s IPO financing. Earlier in his career, Mr. Weaver served as Chief Financial Officer of several other Nasdaq-listed life sciences companies, including Fibrocell Science, Celsion Corp., Poniard Pharmaceuticals, Sirna Therapeutics and Sirna Therapeutics.ILEX Oncology. In addition, Mr. Weaver currently serves as a Director of Egalet Corporation and Atossa Genetics.Genetics, Inc. Mr. Weaver received aan M.B.A. from Boston College, a B.S. in accounting from Trinity University, and a U.S. CPA certification.

Dr. Huertas, age 64,Gregory Williams has served as our Chief MedicalOperating Officer since DecemberJune 2018. Dr. Williams has over 30 years of pharmaceutical and biotechnology experience leading regulatory affairs, compliance, quality, manufacturing, commercial and product development programs. Dr. Williams is an accomplished scientist and seasoned pharmaceutical executive with a solid track record of successful achievement of business, medical, scientific and regulatory goals. His focus is on driving innovation to improve patient care by developing and commercializing new products to address unmet patient and health system needs. While at The Medicines Company, Dr. Williams led development and successful approval of the antihypertensive drug, Cleviprex®. Dr. Williams also worked on the orphan drug programs at NPS Pharmaceuticals, Inc. Most recently, while at Radius Health, Inc., Dr. Williams led the successful first cycle approval by the FDA of TYMLOS™. Dr. Williams brings established relationships with global health authority reviewers, having led the development and/or initial and expanded approvals of several global brands, as well as expertise across a wide range of therapeutic categories, molecule types, dosage forms and technologies. Dr. Williams holds a Ph.D. in Biopharmaceutics from Rutgers University and a M.B.A. from Cornell University.
Mr. David Snow has served as our Chief Business Officer since June 2018. Mr. Snow has over 25 years of experience in the global pharmaceutical industry developing global brands, leading large commercial organizations across major markets, driving transformation and growth, and delivering a successful track record of business development. In his career, Mr. Snow was President of AstraZeneca’s China business and during his tenure, AZ China experienced rapid growth becoming the company’s second largest market with 2014 sales of  $2.2 billion. In his fifteen years with AstraZeneca, he also held key U.S. leadership roles including running a $10 billion U.S. business unit across several therapeutic areas, including oncology. From 2015 until 2017, Mr. Snow was the Chief Commercial Officer of Radius Health, Inc. and was previouslyresponsible for building Radius’ commercial organization and subsequently, the Chief Medical Officersuccessful launch of Private Eloxx beginning in May 2015.TYMLOS™. Prior to joining AZ, Mr. Snow held global and U.S. commercial leadership roles at several other companies including Bristol-Myers Squibb. He served on the RDPAC industry association board in China for several years and was a director of Advanced Health Media, a privately held healthcare services firm in 2017 until its sale to IQVIA later that Dr. Huertas’same year. Mr. Snow received his B.S. in Business Administration from Auburn University, and a M.B.A. from New York University — Leonard N. Stern School of Business.
23

Mr. Neil S. Belloff has served as our Executive Vice President, General Counsel and Corporate Secretary since June 2018. Prior to joining Eloxx, Mr. Belloff was Senior Corporate Counsel at Celgene Corporation, a global biopharmaceutical company, since 2011. Mr. Belloff also served for seven years as Executive Vice President and U.S. Corporate and Securities Counsel at Deutsche Telekom, one of the largest telecommunications companies in the world. Mr. Belloff has more than 30 years of legal and business experience, with Precision Medicinesignificant management and project development responsibilities in business critical areas including risk assessment, strategic planning, regulatory compliance, mergers and acquisitions, capital formation, privacy, pharmaceutical development, and securities matters. In addition to his corporate governance and compliance expertise, Mr. Belloff served as Clinical Leada Senior Attorney-Advisor in the Division of Corporation Finance at the U.S. Securities and HeadExchange Commission in Washington, D.C. Mr. Belloff holds a J.D. from Quinnipiac University School of Precision Medicine for Rare Diseases at Pfizer Worldwide Research & DevelopmentLaw, a M.A. from 2012 until May 2015. He also previously held senior rolesNew York University, a B.A. from Queens College of the City University of New York, and Genzyme, Shire and Amicus Therapeutics. Dr. Huertas is a graduate of Stanford University (MS, Biochemistry), Harvard University (PhD, Cell and Developmental Biology),completed post-graduate studies in the LL.M. Program in Health Sciences and Technology between Harvard Medical School and the Massachusetts Institute of Technology (MD), and the Sloan School of ManagementSecurities Regulation at the Massachusetts Institute of Technology (MS, Management). He trained in Internal Medicine, Rheumatology, and Palliative Care at Massachusetts General Hospital.

Georgetown University Law Center.

24

SECURITY OWNERSHIP OF


CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

The following table sets forth certain information relating to the beneficial ownership of our common stock as of March 31, 2018,April 1, 2019, by (a) each person, or group of affiliated persons, known by us to beneficially own more than five percent (5%) of the outstanding shares of our common stock, (b) each of our directors, (c) each of our named executive officers, and (d) all directors and executive officers as a group.

The number of shares beneficially owned by each entity, person, director or executive officer is determined in accordance with the rules of the SEC, and the information is not necessarily indicative of beneficial ownership for any other purpose. Under such rules, beneficial ownership includes any shares over which the individual has sole or shared voting power or dispositive power as well as any shares that the individual has the right to acquire within 60 days of March 31, 2018April 1, 2019 through the exercise of any stock option, warrants or other rights. Restricted stock units (RSUs) that will vest within 60 days of April 1, 2019 are deemed outstanding and reflected in the Shares of Common Stock Beneficially Owned column and for computing the ownership percentage of the stockholder holding such securities, but are not deemed outstanding for computing the ownership percentage of any other stockholder. Vested RSUs are included as common stock. Shares underlying Performance Stock Units (PSUs) are not deemed outstanding until earned and are not included in the table. Except as otherwise indicated, and subject to applicable community property laws, the persons named in the table have sole voting and dispositive power with respect to all shares of common stock held by that person.

The percentage of shares beneficially owned is computed on the basis of 27,527,73835,945,608 shares of our common stock outstanding as of March 31, 2018.April 1, 2019. Shares of common stock that a person has the right to acquire within 60 days of March 31, 2018,April 1, 2019, are deemed outstanding for purposes of computing the percentage ownership of the person holding such rights, but are not deemed outstanding for purposes of computing the percentage ownership of any other person, except with respect to the percentage ownership of all directors and executive officers as a group. Unless otherwise noted below, the address of the persons listed on the table is c/o Eloxx Pharmaceuticals, Inc., 950 Winter Street, Waltham, MA 02451.

Beneficial Owner

Greater than 5% Stockholders

  Shares of
Common Stock
Beneficially
Owned
   Percentage of
Common Stock
Beneficially Owned
 

Pontifax Funds (1)

   8,789,671    31.93

Technion Funds (2)

   1,403,745    5.10

Catalyst Funds (3)

   1,658,544    6.02

Gilad Shabtai (4)

   3,276,770    11.90

LSP V Coöperatieve U.A. (5)

   2,653,673    9.64

Global Health Science Fund I, L.P. (6)

   1,658,543    6.02

The following table sets forth information concerning the

Greater than 5% StockholdersShares of
Common Stock
Beneficially
Owned
Percentage of
Common Stock
Beneficially Owned
Pontifax Funds(1)
9,139,67125.4%
Technion Funds(2)
1,973,1405.5%
Catalyst Funds(3)
1,836,4415.1%
Menora Mivtachim Holdings Ltd.(4)
1,882,7265.2%
LSP V Coöperatieve U.A.(5)
2,953,6738.2%
Global Health Science Fund I, L.P.(6)
1,658,5434.6%
Directors and Named Executive Officers
Robert Ward(7)
419,8831.2%
Zafrira Avnur, Ph.D.(8)
2,263*
Tomer Kariv(9)
9,139,67125.4%
Martijn Kleijwegt(10)
2,953,6738.2%
Dr. Silvia Noiman, Ph.D., MBA(11)
796,8602.2%
Ran Nussbaum(12)
9,139,67125.4%
Steven D. Rubin(13)
59,120*
Jasbir Seehra, Ph.D.0*
Gadi Veinrib0*
Gregory Weaver(14)
129,270*
Gregory Williams0*
David Snow0*
All directors and executive officers as a group (12 persons) (1) – (15)13,500,74036.8%
25

*
Represents beneficial ownership of less than 1%.
(1)
Based on a Schedule 13D filed with the SEC on January 2, 2018 and subsequent Form 4 filings, Pontifax Management III G.P. (2011) Ltd. (“Management III”) has shared voting and dispositive power with respect to our7,188,186 shares of common stock; Pontifax Management Fund III L.P. has shared voting and dispositive power with respect to 7,188,186 shares of common stock; Pontifax (Cayman) III, L.P. has shared voting and dispositive power with respect to 2,287,937 shares of common stock; Pontifax (Israel) III, L.P. has shared voting and dispositive power with respect to 4,900,249 shares of common stock; Pontifax Management 4 G.P. (2015) Ltd. (“Management 4”) has shared voting and dispositive power with respect to 1,951,485 shares of common stock; Pontifax IV GP L.P. has shared voting and dispositive power with respect to 1,951,485 shares of common stock; Pontifax (Cayman) IV L.P. has shared voting and dispositive power with respect to 468,585 shares of common stock; Pontifax (Israel) IV, L.P. has shared voting and dispositive power with respect to 962,504 shares of common stock; and Pontifax (China) IV L.P. has shared voting and dispositive power with respect to 520,396 shares of common stock. The managing partners of Management III and Management 4 are Tomer Kariv and Ran Nussbaum. The address of the entities affiliated with Pontifax Funds is 14 Shenkar St., Herzeliya, Israel.
(2)
Based on a Schedule 13G filed with the SEC on December 29, 2017, Technion Investment Opportunities Fund L.P. has shared voting and dispositive control with respect to 694,423 shares of common stock and Technion Research and Development Foundation Ltd. has sole voting and dispositive power with respect to 1,278,717 shares of common stock and shared voting and dispositive power with respect to 694,423 shares of common stock. Technion Research and Development Foundation Ltd. is the general partner of Technion Investment Opportunities Fund L.P. The address of the entities affiliated with Technion Funds is Israel Institute of Technology, Technion City, Haifa, 320003 Israel.
(3)
Based on a Schedule 13G/A filed with the SEC on February 6, 2019, Catalyst CEL Management Ltd. has shared voting and dispositive power with respect to 1,836,441 shares of common stock; CEL Catalyst China Israel General Partner Limited has shared voting and dispositive power with respect to 1,836,441 shares of common stock; Catalyst CEL Fund L.P. has shared voting and dispositive power with respect to 229,920 shares of common stock; and CEL CATALYST China Israel Fund L.P. has shared voting and dispositive power with respect to 1,606,521 shares of common stock. The address of the entities affiliated with Catalyst Funds is 28 HaArbaa St., Tel-Aviv 64731 Israel.
(4)
Based on a Schedule 13G filed with the SEC on February 11, 2019, Menora Mivtachim Holdings Ltd. has shared voting and dispositive power with respect to 1,882,726 shares of common stock. The address of Menora Mivtachim Holdings Ltd. is Menora House, 23 Jabotinsky St., Ramat Gan 5251102, Israel.
(5)
Based on a Schedule 13D filed with the SEC on December 29, 2017 and subsequent Form 4 filing. Consists of 2,953,673 shares of common stock held by LSP V Coöperatieve U.A. LSP V Management B.V. is the director and manager of LSP V Coöperatieve U.A. and shares voting power and investment control over shares held by LSP V Coöperatieve U.A. The managing directors of LSP V Management B.V. are Martijn Kleijwegt, Rene Kuijten and named executive officersJoachim Rothe. The address of LSP is Johannes Vermeerplein 9, 1071 DV Amsterdam, the Netherlands.
(6)
Based on a Schedule 13G filed with the SEC on December 29, 2017. Consists of 1,658,543 shares of common stock held by Global Health Science Fund I, L.P. GHS Partnership L.P. is the general partner of Global Health Science Fund I, L.P. and shares voting power and investment control over such shares. GHS Partners Limited is the general partner of GHS Partnership L.P. and shares voting power and investment control over such shares.
(7)
Consists of 120,689 shares of common stock, 249,194 shares of common stock underlying stock options, and 50,000 shares of common stock held by a family foundation of which Mr. Ward is a trustee.
(8)
Consists of 2,263 shares of common stock held in placean IRA indirectly by spouse.
26

(9)
Consists of 9,139,671 shares of common stock of the Pontifax Funds as to which Mr. Kariv may be deemed to share voting power and investment control in his capacity as a managing partner of March 31, 2018.

Directors and Named Executive

Officers

        

Robert Ward (7)

   10,000    *

Tomer Kariv (8)

   8,789,671    31.93

Dr. Silvia Noiman, Ph.D., MBA (9)

   485,223    1.76

Ran Nussbaum (10)

   8,789,671    31.93

Gadi Veinrib

   —      *

Zafrira Avnur, Ph.D.

   2,263    *

Martijn Kleijwegt (11)

   2,653,673    9.64

Steven D. Rubin (12)

   59,120    *

Gregory Weaver (13)

   4,500    *

Dr. Pedro Huertas (14)

   114,814    *

All directors and executive officers as a group (10 persons) (15)

   12,119,264    44.03

*Represents beneficial ownership of less than 1% of the shares of common stock.
Management III and Management 4. Mr. Kariv disclaims beneficial ownership of such shares, except to the extent of his pecuniary interest therein.

(1)Based on a Form 4 filed with the SEC on March 23, 2018. Consists of 2,287,937 shares of common stock held by Pontifax (Cayman) III, L.P., Cayman III, 4,900,249 shares of common stock held by Pontifax (Israel) III, L.P. Israel III, 384,544 shares of common stock held by Pontifax (Cayman) IV L.P., Cayman IV, 789,878 shares of common stock held by Pontifax (Israel) IV, L.P., Israel IV, and 427,063 shares of common stock held by Pontifax (China) IV L.P., China IV. Pontifax Management Fund III L.P., Pontifax III, is the general partner of Cayman III and Israel III. Pontifax Management III G.P. (2011) Ltd., Management III, is the general partner of Pontifax III. As a result, each of Management III and Pontifax III may be deemed to share voting and dispositive power with respect to the shares held by Cayman III and Israel III. Each of Management III and Pontifax III disclaims beneficial ownership of such shares, except to the extent of its pecuniary interest therein. Pontifax IV GP L.P., Pontifax IV, is the general partner of Cayman IV, Israel IV and China IV. Pontifax Management 4 G.P. (2015) Ltd., Management 4, is the general partner of Pontifax IV. As a result, each of Management 4 and Pontifax IV may be deemed to share voting and dispositive power with respect to the shares held by Cayman IV, Israel IV and China IV. Each of Management 4 and Pontifax IV disclaim beneficial ownership of such shares, except to the extent of its pecuniary interest therein. The address of the entities affiliated with Pontifax Funds is 14 Shenkar St., Herzeliya, Israel.
(2)Based on a Schedule 13G filed with the SEC on December 29, 2017. Consists of 694,423 shares of common stock held by Technion Investment Opportunities Fund L.P. and 709,322 shares of common stock held by Technion Research and Development Foundation Ltd. Technion Research and Development Foundation Ltd. is the general partner of Technion Investment Opportunities Fund L.P. and shares voting power and investment control over shares held by Technion Investment Opportunities Fund L.P. The address of the entities affiliated with Technion Funds is Israel Institute of Technology, Technion City, Haifa, 320003 Israel.
(3)Based on a Schedule 13D filed with the SEC on December 29, 2017. Consists of 1,450,894 shares of common stock held by CEL CATALYST China Israel Fund L.P. and 207,650 shares of common stock held by Catalyst CEL Fund L.P. CEL Catalyst China Israel General Partner Limited, General Partner, is the general partner of each of Catalyst CEL Fund L.P. and CATALYST China Israel Fund L.P. and shares voting power and investment control over such shares. Catalyst CEL Management Ltd. is the management company and sole shareholder of General Partner and shares voting power and investment control over such shares. The address of the entities affiliated with Catalyst Funds is 28 Haarbaa St., Tel Aviv 64731 Israel.
(4)Based on a Schedule 13G filed with the SEC on December 29, 2017. Consists of 3,276,770 shares of common stock held by Gilad Shabtai.
(5)Based on a Schedule 13D filed with the SEC on December 29, 2017. Consists of 2,653,673 shares of common stock held by LSP V Coöperatieve U.A. LSP V Management B.V. is the director and manager of LSP V Coöperatieve U.A. and shares voting power and investment control over shares held by LSP V Coöperatieve U.A.
(6)Based on a Schedule 13G filed with the SEC on December 29, 2017. Consists of 1,658,543 shares of common stock held by Global Health Science Fund I, L.P. GHS Partnership L.P. is the general partner of Global Health Science Fund I, L.P. and shares voting power and investment control over such shares. GHS Partners Limited is the general partner of GHS Partnership L.P. and shares voting power and investment control over such shares.
(7)Consists of 10,000 shares purchased at market by Mr. Ward on March 23, 2018.
(8)Consists of 8,789,671 shares of common stock of the Pontifax Funds as to which Mr. Kariv may be deemed to share voting power and investment control in his capacity as a managing partner of Management III and Management 4. Mr. Kariv disclaims beneficial ownership of such shares, except to the extent of his pecuniary interest therein.
(9)Consists of vested options to purchase 485,223 shares of common stock.
(10)Consists of 8,789,671 shares of common stock held by the Pontifax Funds as to which Mr. Nussbaum may be deemed to share voting power and investment control in his capacity as a managing partner of Management III and Management 4. Mr. Nussbaum disclaims beneficial ownership of such shares, except to the extent of his pecuniary interest therein.

(11)Consists of 2,653,673 shares of common stock held by LSP V Coöperatieve U.A. as to which Mr. Kleijwegt may be deemed to share voting power and investment control in his capacity as a managing director of LSP V Management B.V. Mr. Kleijwegt disclaims beneficial ownership of such shares, except to the extent of his pecuniary interest therein.
(12)Consists of vested options to purchase 59,120 shares of common stock.
(13)Consists of 4,500 shares purchased at market by Mr. Weaver on March 23, 2018.
(14)Includes vested options to purchase 114,814 shares of common stock.
(15)Numbers do not compute due to Mr. Kariv and Mr. Nussbaum’s potential deemed shared voting control and investment power over shares of common stock held by the Pontifax Funds.
(10)

Consists of 2,953,673 shares of common stock held by LSP V Coöperatieve U.A. as to which Mr. Kleijwegt may be deemed to share voting power and investment control in his capacity as a managing director of LSP V Management B.V. Mr. Kleijwegt disclaims beneficial ownership of such shares, except to the extent of his pecuniary interest therein.

(11)
Consists of 490,789 shares of common stock, 303,223 shares of common stock underlying stock options, and 2,848 shares of common stock underlying stock options vesting within 60 days (subject to share withholding for taxes on the vesting date).
(12)
Consists of 9,139,671 shares of common stock held by the Pontifax Funds as to which Mr. Nussbaum may be deemed to share voting power and investment control in his capacity as a managing partner of Management III and Management 4. Mr. Nussbaum disclaims beneficial ownership of such shares, except to the extent of his pecuniary interest therein.
(13)
Consists of vested options to purchase 59,120 shares of common stock.
(14)
Consists of 4,500 shares of common stock and vested options to purchase 124,770 shares of common stock.
(15)
Each of Mr. Kariv and Mr. Nussbaum’s report the shares held by the Pontifax Funds due to their potential deemed shared voting and dispositive power over those shares. The shares held by the Pontifax Funds are only included once in the number reported in this row.
27

SECTION 16(A) BENEFICIAL OWNERSHIP REPORTING COMPLIANCE

Section 16(a) of the Exchange Act requires our executive officers, directors and persons who own more than ten percent of a registered class of our equity securities, to file with the SEC initial reports of ownership and reports of changes in ownership of our common stock and other equity securities. Officers, directors and greater than ten percent stockholders are required by SEC regulation to furnish us with copies of all Section 16(a) forms they file.

To our knowledge, based solely on a review of the copies of such reports furnished to us and written representations that no other reports were required, during the fiscal year ended December 31, 2017,2018, all Section 16(a) filing requirements applicable to our officers, directors and greater than ten percent beneficial owners were complied with, except for that onethe inadvertent late filing of a Form 4 report covering one transaction, filed by Mr. Nussbaum; that one report, covering one transaction, filed byof Dr. Heft; that one report, covering one transaction, filed by Opko Health, Inc.

Silvia Noiman with respect to the exercise of stock options on June 6, 2018.

28

EXECUTIVE COMPENSATION

Summary Compensation Table

The following table sets forth information regarding compensation awarded to, earned by or paid to our namedprincipal executive officers, which include ourofficer, principal executivefinancial officer, and the next two most highly compensated executive officers in 2017, during the years ended December 31, 2018 and 2017 and 2016.

(our “named executive officers”).

Summary Compensation Table

Name and Principal

Position (1)

 Year  Salary
($)
  Bonus
($)(2)
  Stock
Awards

($) (3)
  Option
Awards
($) (4)
  Non-Equity
Incentive Plan
Compensation

($)
  Nonqualified
Deferred
Compensation
Earnings ($)
  All Other
Compensation
($) (5)
  Total
($)
 

Robert E. Ward
Chief Executive Officer

  2017   —     —     5,305,696   3,428,806   —     —     —     8,734,502 

Gregory Weaver (6)
Chief Financial Officer

  2017   2,836   —     —     1,569,084   —     —     19   1,571,939 

Pedro Huertas, MD, Ph.D. (6)
Chief Medical Officer

  2017   9,305   3,107   —     —     —     —     1,391   13,803 

Dr. Silvia Noiman, Ph.D., MBA (6)
Former Chief Executive Officer

  2017   4,116   1,061   —     —     —     —     —     5,177 

The following table describes

Name and Principal Position(1)
YearSalary
($)
Bonus
($)
Stock
Awards
($)(2)
Option
Awards
($)(3)
Non-Equity
Incentive
Plan
Compensation
($)(4)
All Other
Compensation
($)(5)
Total
($)
Robert E. Ward
Chief Executive Officer
2018452,885425,000(6)25,759903,644
20176,9235,305,6963,428,8068,741,425
Gregory Weaver
Chief Financial Officer
2018347,212138,00037,009522,221
20172,8361,569,084191,571,939
Gregory Williams(7)
Chief Operating Officer
2018244,71250,000(8)5,655,000(9)78,08210,4876,038,281
David P. Snow (10)
Chief Business Officer
2018197,4603,770,000(9)78,08283,037(11)4,128,579
(1)
Reflects the compensation awarded to, earnedposition held by or paid tothe named executive officers who served priorofficer at the end of 2018.
(2)
Amounts reflect the aggregate grant date fair value of restricted stock unit granted during the relevant fiscal year calculated in accordance with FASB ASC Topic 718. Assumptions used in the calculation of these amounts are included in Note 11 to the Transactionour audited financial statements included in our Annual Report on Form 10-K for the fiscal yearsyear ended December 31, 20172018. These amounts do not reflect the actual economic value that may be realized by the named executive officer upon the vesting of the restricted stock unit or the sale of the common stock such restricted stock unit. The grant date fair value was not adjusted to take into account any estimated forfeitures.
(3)
Amounts reflect the aggregate grant date fair value of option awards granted during the relevant fiscal year calculated in accordance with FASB ASC Topic 718. Assumptions used in the calculation of these amounts are included in Note 11 to our audited financial statements included in our Annual Report on Form 10-K for the year ended December 31, 2018. These amounts do not reflect the actual economic value that may be realized by the named executive officer upon the vesting of the stock options, the exercise of the stock options, or the sale of the common stock underlying such stock options. The grant date fair value was not adjusted to take into account any estimated forfeitures.
(4)
Amounts represent amounts payable upon the achievement of pre-established annual corporate goals. The Company’s Compensation Committee determined to pay Mr. Ward, Mr. Weaver, Dr. Williams, and 2016. The following amountsMr. Snow annual cash incentive plan awards equal to 100% of such named executive officer’s target award for performance in 2018.
(5)
Amounts shown in the “All Other Compensation” column include the Company’s contributions to a tax qualified 401(k) plan and insurance premiums for life insurance and medical payments that were earnedpaid consistent with the Company’s policies and available to all employees.
(6)
Amount includes a transaction bonus totaling $200,000 made pursuant to the terms of Mr. Ward’s employment agreement.
(7)
Dr. Williams was appointed Chief Operating Officer, effective June 25, 2018, and received a pro-rated amount of his annual salary of  $375,000 and his annual cash incentive plan award for services renderedhis service in 2018.
(8)
Amounts represent sign-on bonus payments paid in 2018 pursuant to Sevionthe terms of Mr. Williams’ employment agreement.
29

(9)
Amount includes an equity award received pursuant to the terms of their respective employment agreement.
(10)
Mr. Snow was appointed Chief Business Officer, effective June 25, 2018, and received a pro-rated amount of his annual salary of  $375,000 and his annual cash incentive plan award for his service in 2018.
(11)
Amount includes consulting fees of  $61,355 paid prior to the Transaction.

Name and Principal

Position (1)

 Year  Salary
($)
  Bonus
($)(2)
  Stock
Awards

($) (3)
  Option
Awards
($) (4)
  Non-Equity
Incentive Plan
Compensation

($)
  Nonqualified
Deferred
Compensation
Earnings ($)
  All Other
Compensation
($) (5)
  Total
($)
 

David Rector

  2017   90,000   —     —     132,165   —     —     —     222,165 

Former Chief Executive Officer

  2016   90,000   —     —     —     —     —     —     90,000 

James Graziano

  2017   121,087   —     —     —     —     —     207,619 (7)   328,706 

Former Chief Technology Officer

  2016   133,606   —     —     —     —     —     1,413 (8)   135,019 

Miguel de los Rios

  2017   86,941   —     —     —     —     —     172,370(9)   258,861 

Former Vice President of Research and Development

  2016   108,366   —     —     —     —     —     —     108,366 

Vaughn Smider, M.D., Ph.D.

  2017   39,538   —     —     —     —     —     58,008 (10)   97,546 

Former Chief Scientific Officer

  2016   78,154   —     —     —     —     —     —     78,154 

(1)

Reflects the position held by the named executive officer at the end of 2017 or, for persons no longer serving atyear-end, the executive’s final position held in 2017. Effective December 19, 2017, Mr. Rector, Mr. Graziano, Mr. de los Rios and Dr. Smider resigned from service. Following the consummation of the Transaction on December 20, 2017, Dr. Noiman was appointed as our Chief Executive Officer. On December 26, 2017, Dr. Noiman resigned from service, and Mr. Ward was appointed as our Chief

Mr. Snow’s appointment as Chief Business Officer on June 25, 2018.

Executive Officer. Also effective on December 20, 2017, Mr. Weaver was appointed as our Chief Financial Officer and Dr. Huertas was appointed as our Chief Medical Officer, both of whom served in these positions with Private Eloxx prior to the Transaction.
(2)Amounts represent annual cash bonuses paid to Dr. Noiman, pursuant to her consulting agreement, and to Dr. Huertas pursuant to his offer letter, as described below.
(3)Amounts reflect the aggregate grant date fair value of stock awards granted during the relevant fiscal year calculated in accordance with FASB ASC Topic 718. Assumptions used in the calculation of these amounts are included in Note 10 to our audited financial statements included in our Annual Report on Form10-K for the year ended December 31, 2017. These amounts do not reflect the actual economic value that may be realized by the named executive officer upon the vesting of the stock options, the exercise of the stock options, or the sale of the common stock underlying such stock options. The grant date fair value was not adjusted to take into account any estimated forfeitures.
(4)Amounts reflect the aggregate grant date fair value of option awards granted during the relevant fiscal year calculated in accordance with FASB ASC Topic 718. Assumptions used in the calculation of these amounts are included in Note 10 to our audited financial statements included in our Annual Report on Form10-K for the year ended December 31, 2017. These amounts do not reflect the actual economic value that may be realized by the named executive officer upon the vesting of the stock options, the exercise of the stock options, or the sale of the common stock underlying such stock options. The grant date fair value was not adjusted to take into account any estimated forfeitures.
(5)Amounts shown in the “All Other Compensation” column include severance and vacation payments, along with Company contributions to a tax qualified 401(k) plan and insurance premiums for medical payments, that were paid consistent with the Company’s policies to, or on behalf of, our currently employed named executive officers in 2017 and 2016.
(6)The amounts disclosed for Mr. Weaver and Drs. Noiman and Huertas reflect only the amounts earned for services rendered to the Company after the Transaction became effective. Compensation earned by Mr. Weaver and Drs. Noiman and Huertas for services rendered to Eloxx Private are not included above.
(7)Amount represents a severance payment, vacation pay out payment, and insurance premiums for medical payments for the amounts of $122,500, $17,854, and $67,265, respectively.
(8)Amount represents a vacation payout payment.
(9)Amount represents a severance payment, vacation pay out payment, and insurance premiums for medical payments for the amounts of $87,500, $17,605, and $67,265, respectively.
(10)Amount represents a severance payment and vacation pay out payment for the amounts of $40,000 and $18,008, respectively.

Outstanding Equity Awards at FiscalYear-End

The following table shows the equity awards held by our named executive officers, who served post-Transaction, as of December 31, 2017. 2018.
Option AwardsStock Awards
NameGrant
Date
Number of
Securities
Underlying
Unexercised
Options (#)
Exercisable
Number of
Securities
Underlying
Unexercised
Options
(#) Unexer-
cisable
Equity
Incentive
Plan
Awards:
Number of
Securities
Underlying
Unexercised
Unearned
Options
(#)
Option
Exercise
Price
($)
Option
Expiration
Date
Number of
Shares or
Units of
Stock that
Have Not
Vested
(#)
Market Value
of Shares of
Units of Stock
That Have Not
Vested
($)(1)
Equity
Incentive
Plan
Awards:
Number of
Unearned
Shares,
Units or
Other Rights
That Have
Not Vested
(#)
Equity
Incentive
Plan
Awards:
Market or
Value of
Unearned
Shares,
Units or
Other Rights
That Have
Not Vested
($)(1)
Robert E. Ward12/26/2017213,595427,19022,4278.0012/26/2027427,1905,130,55222,427269,348
Gregory Weaver12/19/201799,816299,4506.0012/19/2027
Gregory Williams, Ph.D.6/25/2018300,00018.856/25/2028
David P. Snow6/25/2018200,00018.856/25/2028
(1)
The number of securities underlying unexercised stock options and the stock option exercise prices included in the table reflect the conversionmarket value of the stock options that occurred in connection withawards is determined by multiplying the Transaction, as described above.

    Option Awards Stock Awards
Name Grant
Date
 Number of
Securities
Underlying
Unexercised
Options (#)
Exercisable
 

Number
of
Securities
Underlying
Unexercised
Options
(#) Unexer-

cisable

 

Equity

incentive

plan
awards:
Number of

securities

underlying

unexercised

unearned

options

(#)

 

Option
Exercise
Price

($)

  Option
Expiration
Date
 

Number
of shares
or units
of stock
that
have not
vested

(#)

 

Market
value of
shares of
units of
stock that
have not
vested

($) (1)

 

Equity
incentive
plan
awards:
Number
of
unearned
shares,
units or
other
rights
that have
not
vested

(#)

 

Equity
incentive
plan
awards:
Market
or value
of
unearned
shares,
units or
other
rights
that have
not
vested

($) (1)

Robert E. Ward

 12/26/2017 —   640,785(2) 22,427(3)  8.00  12/26/2027 640,785(2) 5,126,280 22,427(3) 179,416

Gregory Weaver (*)

 12/20/2017(4) —   399,266 —    6.00  12/20/2027 —   —   —   —  

Pedro Huertas, MD, Ph.D. (*)

 7/16/2017 (5) 900 13,495 —    0.96  7/16/2027 —   —   —   —  
 1/24/2016 (6) 14,558 10,399 —    1.00  1/24/2026 —   —   —   —  
 5/1/2015 (4) 75,227 45,136 —    1.00  5/1/2025 —   —   —   —  

Dr. Silvia Noiman, Ph.D., MBA (*)

 7/16/2017 (5) 2,847 42,709 —    0.96  7/16/2027 —   —   —   —  
 1/24/2016 (6) 40,763 29,117 —    1.00  1/24/2026 —   —   —   —  
 11/16/2014 (7) 74,871 —   —    0.80  1/16/2024 —   —   —   —  
 4/26/2014 (7) 349,400 —   —    0.01  4/26/2024 —   —   —   —  

The following table showsnumber of shares subject to such award times $12.01, which is the equity awards held by our named executive officers who served prior toclosing price of the Transaction, as ofCompany’s common stock on December 31, 2017. The number2018, the last business day of securities underlying unexercised stock options and the stock option exercise prices included in the table reflect the conversion of the stock options that occurred in connection with the Transaction, as described above.

    Option Awards Stock Awards
Name Grant
Date
 Number of
Securities
Underlying
Unexercised
Options (#)
Exercisable
 

Number
of
Securities
Underlying
Unexercised
Options
(#) Unexer-

cisable

 

Equity

incentive

plan awards:
Number of

securities

underlying

unexercised

unearned

options

(#)

 

Option
Exercise
Price

($)

 Option
Expiration
Date
 

Number of
shares or
units of
stock that
have not
vested

(#)

 

Market value
of shares of
units of stock
that have not
vested

($) (1)

 

Equity
incentive
plan
awards:
Number
of
unearned
shares,
units or
other
rights
that have
not
vested

(#)

 

Equity incentive
plan awards:
Market or value
of unearned
shares, units or
other rights
that have not
vested

($) (1)

David Rector

 12/19/2017(7) 27,500 —   —   6.00 12/19/2027 —   —   —   —  
 11/18/2014(7) 1,847 —   —   16.60 11/18/2024 —   —   —   —  
 5/14/2014(7) 1,053 —   —   55.40 5/14/2024 —   —   —   —  
 9/13/2013(7) 185 —   —   108.00 9/13/2023 —   —   —   —  
 5/17/2013(7) 122 —   —   86.00 5/17/2023 —   —   —   —  
 2/19/2013(7) 48 —   —   264.00 2/19/2023 —   —   —   —  
 11/16/2012(7) 176 —   —   330.00 11/16/2022 —   —   —   —  
 5/16/2012(7) 5 —   —   410.00 5/16/2022 —   —   —   —  
 2/16/2012(7) 7 —   —   480.00 2/16/2022 —   —   —   —  
 11/16/2011(7) 41 —   —   400.00 11/16/2021 —   —   —   —  
 9/30/2011(7) 115 —   —   460.00 9/30/2021 —   —   —   —  
 5/17/2011(7) 13 —   —   540.00 5/17/2011 —   —   —   —  
 2/14/2011(7) 9 —   —   580.00 5/14/2021 —   —   —   —  
 11/17/2010(7) 96 —   —   520.00 11/17/2020 —   —   —   —  
 5/20/2010(7) 5 —   —   1,220.00 5/20/2020 —   —   —   —  
 2/19/2010(7) 25 —   —   580.00 5/19/2020 —   —   —   —  
 11/19/2009(7) 43 —   —   780.00 11/19/2019 —   —   —   —  
 5/6/2009(7) 5 —   —   1,180.00 5/6/2019 —   —   —   —  
 2/20/2009(7) 6 —   —   940.00 2/20/2019 —   —   —   —  
 11/19/2008(7) 38 —   —   1,200.00 11/18/2019 —   —   —   —  

James Graziano

 11/18/2014(7) 773 —   —   16.60 11/18/2024 —   —   —   —  

Miguel de los Rios

 11/18/2014(7) 1,275 —   —   53.00 11/18/2024 —   —   —   —  
 5/16/2014(7) 5,654 —   —   53.00 5/16/2024 —   —   —   —  

Vaughn Smider, M.D., Ph.D.

 11/18/2014(7) 1,266 —   —   16.60 11/18/2024 —   —   —   —  

(1)The market value of the stock awards is determined by multiplying the number of shares subject to such award times $8.00, which is the closing price of the Company’s common stock on December 29, 2017, the last business day of 2017.
(2)Subject to time-based vesting over a four-year period withone-third vesting on the first anniversary of the date of grant, andone-twelfth vesting on a quarterly basis thereafter, subject to Mr. Ward’s continued employment or service with the Company through each applicable vesting date. Vesting may also be accelerated following the achievement of certain Company performance milestones.
(3)Will become earned upon achievement of the first successful completion of aPhase-2B study with respect to any indication and will vest in full on the date earned, subject to Mr. Ward’s continued employment or service with the Company through the applicable vesting date.
2018.

(4)Subject to time-based vesting over a four-year period withone-quarter vesting on the first anniversary of the date of grant, andone-twelfth vesting on a quarterly basis thereafter, subject to the named executive officer’s continued employment or service with the Company through each applicable vesting date.
(5)Subject to time-based vesting over a four-year period on a quarterly basis beginning on the first quarter following the date of grant, subject to the named executive officer’s continued employment or service with the Company through each applicable vesting date.
(6)Subject to time-based vesting over a three-year period on a quarterly basis beginning on the first quarter following the date of grant, subject to the named executive officer’s continued employment or service with the Company through each applicable vesting date.
(7)This award was fully vested as of December 31, 2017.
(*)Prior to the Transaction, the board of directors of Eloxx Limited, upon the recommendation of its compensation committee, granted stock options. Upon completion of the Transaction, outstanding stock options were converted into stock options with respect to the Company’s common stock, on substantially the same terms and conditions as were applicable immediately prior to the Transaction. The number of shares of the Company common stock subject to each converted stock option was determined by multiplying the number of ordinary shares of Eloxx Limited stock subject to such award by the exchange ratio used in the Transaction and the exercise price of each converted award was determined by dividing the exercise price of such award by the exchange ratio. The awards were also adjusted to reflect the reverse stock split that was effective on December 19, 2017.

Employment Arrangements

The initial terms and conditions of employment for each of our named executive officers are set forth in either employee offer letters.letters or employment agreements. Each of our named executive officers is anat-will employee. The following table sets forth employee, subject to the current base salaries and fiscal year 2018 bonus targets for our named executive officers:

Named Executive

Officer

  Fiscal
Year 2018
Salary ($)
   Fiscal
Year 2018
Bonus
Target ($)
 

Robert E. Ward

  $450,000   $225,000 

Gregory Weaver

  $345,000   $138,000 

Dr. Pedro Huertas, MD, Ph.D.

  $346,500   $138,600 

terms of applicable offer letters or employment agreements. We have entered into agreements with each of our named executive officers setting forforth the terms of their service or employment with us. Below is a description of the material terms of each of the agreements.

Employment Agreement with Robert E. Ward

Pursuant to his employment agreement with us effective as of December 26, 2017, Mr. Ward is entitled to anWard’s annual base salary of  $450,000 which will bewas increased to $500,000 effective January 1, 2019 following the successful consummation of the first transaction or series of related transactionsCompany’s capital raise in which the Company sells securities for capital raising purposes which results in gross proceeds to the Company of at least $30 million, but in no event earlier than January 2019.April 2018. Mr. Ward is also eligible to earn an annual cash bonus, with a target of 50% of his annual base salary, subject to the achievement of performance milestones determined by our Board. Mr. Ward is also eligible to earn transaction bonuses as follows: (i) a bonus of  $200,000 following the consummation of a first transaction between the Company and a strategic pharmaceutical company, and (ii) a bonus of  $200,000 following the successful consummation of a fundraising by the Company which exceeds $10 million, in each case, as determined by our Board in its reasonable discretion. Mr. Ward is also eligible to participate in the Company’s benefit programs as made generally available to other senior executives and is eligible to receive annual equity grants, in the discretion of our Board or any committee thereof.

30

In connection with his hire, Mr. Ward’s employment agreement also provides for him to be granted certain inducement awards, subject to performance- and/or time-based vesting conditions, as applicable. These awards are described further below under “Equity Compensation—Inducement“Inducement Grants Made to Mr. Ward.”

Upon termination of Mr. Ward’s employment by the Company without causeCause or by Mr. Ward for good reasonGood Reason (each such term as defined in the employment agreement), Mr. Ward will be entitled to (1) continued payments of his base salary for 12 months, (2) payments for COBRA coverage at applicable rates for 12 months, (3) any annual bonus earned but unpaid for the year immediately prior to his termination date, (4) apro-rata portion of the annual bonus to which he would otherwise have been entitled for the year of termination, based on achievement of performance goals as determined by our Board in good faith, (5) accelerated vesting of 25% his unvested shares subject to all stock options, restricted stock units and other equity awards, and (6) an additional nine months in which to exercise any vested stock options (but not to exceed the original term of the award). If Mr. Ward’s employment is terminated by the Company without causeCause or by Mr. Ward for good reasonGood Reason within 24 months following (a) any consolidation or merger of the Company in which the Company is not the continuing or surviving corporation, other than a transaction in which the holders of Common Stockcommon stock (on an as converted basis) immediately prior thereto have the same, or substantially similar, proportionate ownership of Common Stockcommon stock (on an as converted basis) of the surviving corporation immediately after the transaction and a transaction in which the holders of Common Stockcommon stock (on an as converted basis) immediately prior thereto own a majority of the voting power of the surviving corporation; or (b) any sale, exchange or other transfer (in one transaction or a series of related transactions) of all or substantially all the assets or all or substantially all of the outstanding and issued shares of the Company (a Significant Event“Significant Event”), he will be entitled to (1) continued payments of his base salary for 18 months, (2) payments for COBRA coverage at applicable rates for 18 months, (3) any annual bonus earned but unpaid for the year immediately prior to his termination date, (4) payment of his full annual bonus to which he would otherwise have been entitled for the year of termination, (5) accelerated vesting of all of his unvested shares subject to all stock options, restricted stock units and other equity awards, and (6) an additional 12 months in which to exercise any vested stock options (not to exceed the original term of the award). Mr. Ward is also eligible for certain tax gross up benefits in the event that payments to him under the employment agreement are subject to Section 280G and 4999 of the Internal Revenue Code.

If Mr. Ward’s employment is terminated by the Company for causeCause or by Mr. Ward without good reason, the Company shall pay Mr. Ward (1) any unpaid base salary through the date of termination and any accrued vacation; (2) reimbursement for any unreimbursed expenses owed to Mr. Ward; and (iii) all other payments and benefits to which Mr. Ward is entitled under the terms of any applicable compensation arrangement or benefit, equity or other plan or program, including but not limited to any applicable insurance benefits, payable on the next regularly scheduled Company payroll date following the date of termination or earlier if required by applicable law only, and shall not be obligated to make any additional payments to Mr. Ward.

Employment Agreement and Offer Letter with Gregory Weaver

On October 2, 2017, Eloxx Limited entered into an offer letter with

Inducement Grants Made to Mr. Weaver, which we assumed in the Transaction. Ward
Pursuant to his employment agreement, on December 26, 2017, Mr. Ward received the offer letter Mr. Weaver was entitledfollowing inducement awards pursuant to an annual base salaryinducement plan approved by our Board: 22,427 stock options and 22,427 restricted stock units awards, both of $345,000which will become earned and waswill vest upon the date that marks the first successful completion of a Phase-2b study with respect to any indication, subject to Mr. Ward’s continued service with us through such date; and 640,785 stock options and 640,785 restricted stock units awards, both of which will vest one-third on the first anniversary of the date of grant, and one-twelfth at the end of each quarter thereafter, subject to Mr. Ward’s continued service through the applicable vesting dates. Mr. Ward’s time-based awards may also eligible to earn an annual cash bonus, with a target of 40% of his annual base salary, basedbe accelerated upon the achievement of certain Company performance milestones determined by our Board. Mr. Weaver’s offer letter also provided for him to be grantedmilestones. The stock options undergranted to Mr. Ward have an exercise price equal to $8.00, which was the 2013 Plan in connectionclosing price of our common stock on the date of grant.
31

Employment Agreement with the Transaction, which stock options were granted on December 20, 2017, subject to time-based vesting conditions and additional terms and conditions as set forth in the applicable award agreement.

Gregory Weaver

On March 12, 2018, we entered an employment agreement with Mr. Weaver, pursuant to which he is entitled to receive a base salary at an annual rate of  $345,000 payable bimonthly during the term of his employment. Heand is also eligible to earn an annual performance-based bonus of up to 40% of his base salary at the discretion of the Board or any committee thereof.

Upon the termination of Mr. Weaver’s employment agreement by the Company without causeCause or a resignation by Mr. Weaver for good reason,Good Reason (each such term as defined in the employment agreement), Mr. Weaver will be entitled to (1) continued payments of his base salary for 12 months, (2) payments for COBRA coverage at applicable rates for 12 months, (3) any Annual Bonus (as defined in the employment agreement) earned but unpaid for the year immediately prior to the date his employment terminated,(4) a pro-rata portion of the Target Bonus (as defined in the employment agreement) based the number of days that Mr. Weaver was employed during such performance year or achievement of performance goals as determined by the Board in good faith, depending on whether performance goals were established as of the date of termination, (5) accelerated vesting of an additional 25% of the total shares subject to all of his stock options, restricted stock units and other equity awards, and (6) a post-termination stock option exercise period for the shorter of 9 months or for the remaining term of the award.

If Mr. Weaver’s employment is terminated by the Company without causeCause or Mr. Weaver resigns for good reasonGood Reason within 24 months following a Significant Event, he will be entitled to (1) continued payments of his base salary for 18 months, (2) payments for COBRA coverage at applicable rates for 18 months, (3) any Annual Bonus (as defined in the employment agreement) earned but unpaid for the year immediately prior to the date his employment terminated, (4) the full Target Bonus (as defined in the Weaver Agreement) for the performance year in which his employment terminated, (5) accelerated vesting of all of the unvested shares subject to all of his stock options, restricted stock units and other equity awards, and (6) a post-termination stock option exercise period for the shorter of 12 months or for the remaining term of the award.

If Mr. Weaver’s employment is terminated by the Company for causeCause or by Mr. Weaver without good reason, the Company shall pay Mr. Weaver (1) any unpaid base salary through the date of termination and any accrued vacation; (2) reimbursement for any unreimbursed expenses owed to Mr. Weaver; and (iii) all other payments and benefits to which Mr. Weaver is entitled under the terms of any applicable compensation arrangement or benefit, equity or other plan or program, including but not limited to any applicable insurance benefits, payable on the next regularly scheduled Company payroll date following the date of termination or earlier if required by applicable law only, and shall not be obligated to make any additional payments to Mr. Weaver.

payments.

Employment Agreement and Offer Letter with Pedro Huertas

On April 16, 2017, Eloxx LimitedGregory Williams

The Company entered into an offer letteremployment agreement with Dr. Huertas, which we assumed inMr. Williams effective as of June 25, 2018 wherein he agreed to serve as the Transaction.Company’s Chief Operating Officer reporting to the Chief Executive Officer of the Company. Pursuant to the offer letter Dr. Huertas wasagreement, Mr. Williams is entitled to an annual base salary of $300,000$375,000 and wasis also eligible to earn an annual cash bonus, with a target of 30%40% of his annual base salary, based upon the achievement of performance milestones determined by our Board. Dr. Huertas wasMr. Williams’ agreement also entitledprovided for a signing bonus of  $50,000 and the grant of stock options to participate in our vision, health and dental insurance plans, as well as our 401(k) retirement plan, and to vacation and business expense reimbursement benefits. Pursuant to his offer letter, Dr. Huertas also received certainpurchase 300,000 shares of common stock option grants and aone-time cash bonus in connection with his hire in 2015.

On March 12, 2018, we entered into an employment agreement with Dr. Huertas, pursuant to which Dr. Huertas is entitled to receive a base salary at an annual rateexercise price of  $346,500, payable bimonthly during$18.85 (the closing market price on the termdate of his employment. He is also eligiblegrant). The stock options were issued under the 2018 Plan and will vest and become exercisable with respect to earn an annual, performance-based bonus with a target bonus of up to 40% of his base salary, at the discretion1/3 of the Board. Under the employment agreement, the Company will grant to Dr. Huertas an option to purchase 104,725 shares of the Company’s common stock (the “Huertas Option Award”) and a restricted stock unit award (the “Huertas RSU Award”) representing 104,725 shares of the Company’s common stock under the Company’s 2018 Equity Incentive Plan (the “2018 Plan”), as soon as possible after such equity plan becomes effective. The Huertas Option Award and the Huertas RSU Award are each subject to vesting over four yearswith one-fourth of the grant vesting on the first anniversary of the granteffective date (the “Cliff Vesting Date”)of the Agreement and one-sixteenthwith respect to an additional 1/12 of the grant vestingshares on each successive quarterly anniversary of the Cliff Vesting Date. Thegrant date thereafter, subject to continued employment agreement is terminable at will by eitherwith the Company through each such date. In addition, the vesting of the stock options granted, and any future stock options, restricted stock units or Dr. Huertas.

other equity compensation awards will be accelerated and become fully vested and exercisable or payable, as the case may be, upon the occurrence of a Significant Event (as defined in the 2018 Plan). Mr. Williams will be entitled to participate in all employee benefit plans that the Company generally makes available to its senior executives (other than severance plans) from time to time.

32

Upon the termination of theMr. Williams’ employment agreement by the Company without causeCause or a resignation by Dr. HuertasMr. Williams for good reason, Dr. HuertasGood Reason (each such term as defined in the employment agreement), Mr. Williams will be entitled to (1) continued payments of his base salary for 12 months, (2) payments for COBRA coverage at applicable rates for 12 months, (3) any Annual Bonus (as defined

in the employment agreement) earned but unpaid for the year immediately prior to the date his employment terminated,(4) a pro-rata portion of the Target Bonus (as defined in the employment agreement) based the number of days that Dr. HuertasMr. Williams was employed during such performance year or achievement of performance goals as determined by the Board in good faith, depending on whether performance goals were established as of the date of termination, and (5) pursuant to the 2018 Plan accelerated vesting of an additional 25% of the total shares subject to all of his stock options, restricted stock units and other equity awards, and (6) a port-terminationpost-termination stock option exercise period for the shorter of 9 months or for the remaining term of the award.

If Dr. Huertas’sMr. Williams’ employment is terminated by the Company without causeCause or by Dr. HuertasMr. Williams resigns for good reasonGood Reason within 24 months following a Significant Event, he will be entitled to (1) continued payments of his base salary for 18 months, (2) payments for COBRA coverage at applicable rates for 18 months, (3) any Annual Bonus (as defined in the employment agreement) earned but unpaid for the year immediately prior to the date his employment terminated, (4) the full Target Bonus (as defined in the agreement) for the performance year in which his employment terminated, and (5) pursuant to the 2018 Plan, accelerated vesting of all of the unvested shares subject to all of his stock options, restricted stock units and other equity awards, and (6) a post-termination stock option exercise period for the shorter of 12 months or for the remaining term of the award.

If Dr. Huertas’sMr. Williams’ employment is terminated by the Company for causeCause or by Dr. HuertasMr. Williams without good reason, the Company shall pay Dr. HuertasMr. Williams (1) any unpaid base salary through the date of termination and any accrued vacation; (2) reimbursement for any unreimbursed expenses owed to Dr. Huertas;Mr. Williams; and (iii) all other payments and benefits to which Dr. HuertasMr. Williams is entitled under the terms of any applicable compensation arrangement or benefit, equity or other plan or program, including but not limited to any applicable insurance benefits, payable on the next regularly scheduled Company payroll date following the date of termination or earlier if required by applicable law only, and shall not be obligated to make any additional payments to Dr. Huertas.

Consultingpayments.

Employment Agreement with and Resignation of Silvia Noiman, Ph.D.

Pursuant to her consultingDavid P. Snow

The Company entered into an employment agreement with Eloxx Limited on December 1, 2014, which we assumed inMr. Snow effective as of June 25, 2018 wherein he agreed to serve as the Transaction, Dr. Noiman, who served as Sevion’sCompany’s Chief Business Officer reporting to the Chief Executive Officer for a brief time period followingof the Transaction, wasCompany. Pursuant to the agreement, Mr. Snow is entitled to a monthly consulting feean annual base salary of NIS 60,000 + VAT (approximately $17,000 USD) for her services as Chief Executive Officer$375,000 and wasis also eligible to earn an annual cash bonus, with a target of up to three times her monthly consulting fee40% of his annual base salary, based onupon the achievement of performance milestones to be determined by the compensation committee and approved by our Board. Dr. Noiman voluntarily resigned from her position as our Chief Executive OfficerMr. Snow’s agreement also provided for the grant of stock options to purchase 200,000 shares of common stock at an exercise price of  $18.85 (the closing market price on December 26, 2017.

On March 13,the date of grant). The stock options were issued under the 2018 Dr. Noiman entered into a Memorandum of Understanding (the “Noiman Agreement”)Plan and will vest and become exercisable with us in connection with the terminationrespect to 1/3 of the consulting service relationship betweenshares on the Company and Dr. Noiman on January 15, 2018. Under the Noiman Agreement, Dr. Noiman is entitled to receive 900,000 NIS (approximately $257,000 USD) in cash within ten daysfirst anniversary of the effective date of the Noiman Agreement. The Company will also grant Dr. Noiman a fully-vested optionAgreement and with respect to purchase 141,389 sharesan additional 1/12 of the Company’s commonshares on each quarterly anniversary of the grant date thereafter, subject to continued employment with the Company through each such date. In addition, the vesting of the stock options granted, and 141,389any future stock options, restricted stock units or other equity compensation awards will be accelerated and become fully vested sharesand exercisable or payable, as the case may be, upon the occurrence of a Significant Event (as defined in the 2018 Plan). Mr. Snow will be entitled to participate in all employee benefit plans that the Company generally makes available to its senior executives (other than severance plans) from time to time.

Upon the termination of Mr. Snow’s employment agreement by the Company without Cause or a resignation by Mr. Snow for Good Reason (each such term as defined in the employment agreement), Mr. Snow will be entitled to (1) continued payments of his base salary for 12 months, (2) payments for COBRA coverage at applicable rates for 12 months, (3) any Annual Bonus (as defined in the employment agreement) earned but unpaid for the year immediately prior to the date his employment terminated, (4) a pro-rata portion of the Company’s common stock,Target Bonus (as defined in the employment agreement) based the number of days that Mr. Snow was employed during such performance year or achievement of performance goals as soondetermined by the Board in good faith, depending on whether performance goals were established as practicable after adoptionof the
33

date of termination, and (5) pursuant to the 2018 Plan accelerated vesting of an additional 25% of the 2018 Plan. Dr. Noiman continuestotal shares subject to provide servicesstock options, restricted stock units and other equity awards, and a post-termination stock option exercise period for the shorter of 9 months or for the remaining term of the award.
If Mr. Snow’s employment is terminated by the Company without Cause or Mr. Snow resigns for Good Reason within 24 months following a Significant Event, he will be entitled to (1) continued payments of his base salary for 18 months, (2) payments for COBRA coverage at applicable rates for 18 months, (3) any Annual Bonus (as defined in the employment agreement) earned but unpaid for the year immediately prior to the Company as a director but does not receive any compensation for her servicesdate his employment terminated, (4) the full Target Bonus (as defined in such capacity.

Consulting Agreement with and Resignation of David Rector (former CEO of Sevion)

On January 9, 2015, Sevion entered into a consulting agreement with The David Stephen Group LLC, an entity wholly-owned and controlled by David Rector, who formerly served as Sevion’s Chief Executive Officer, setting forth Mr. Rector’s monthly compensation amountthe agreement) for the provisionperformance year in which his employment terminated, and (5) pursuant to the 2018 Plan, accelerated vesting of his services, as well as certain other standard provisions, such as confidentiality and invention assignment restrictive covenants. Pursuant to his consulting agreement, Mr. Rector was originally entitled to a monthly consulting fee of $10,000 per month, which was increased by our compensation committee effective in June 2015 to $15,000 per month, and reduced by our compensation committee effective in March 2016 to $5,000 per month.

Mr. Rector voluntarily resigned from his position at Sevion as partall of the Transaction, effective asunvested shares subject to stock options, restricted stock units and other equity awards, and a post-termination stock option exercise period for the shorter of December 19, 2017. In connection with his resignation he was granted 27,500 options (split adjusted) with a total value $132,165,12 months or for the remaining term of the award.

If Mr. Snow’s employment is terminated by the Company for Cause or by Mr. Snow without good reason, the Company shall pay Mr. Snow (1) any unpaid base salary through the date of termination and any accrued vacation; (2) reimbursement for any unreimbursed expenses owed to Mr. Snow; and (iii) all other payments and benefits to which vested immediately.

Mr. Snow is entitled under the terms of any applicable compensation arrangement or benefit, equity or other plan or program, including but not limited to any applicable insurance benefits, payable on the next regularly scheduled Company payroll date following the date of termination or earlier if required by applicable law only, and shall not be obligated to make any additional payments.

Executive Benefits and Perquisites

All of our full-time employees, including Messrs. Ward and Weaver and Dr. Huertas,our named executive officers, are eligible to participate in our health and welfare plans, including medical, dental and vision benefits. Messrs. Ward, Weaver and Dr. HuertasOur named executive officers participate in these plans on the same basis as other eligible employees.

Prior to their resignations, both Dr. Noiman and Mr. Rector were engaged as consultants and did not receive any perquisites or participate in any benefit plans of the Company.

The value of these benefits is included above in the “All Other Compensation” column of the summary compensation table.

Retirement Plans

We maintain a 401(k) plan in which U.S. employees of the Company who meet certain eligibility requirements, including Messrs. Ward and Weaver and Dr. Huertas,our named executive officers, are eligible to participate. The 401(k) plan is a U.S.tax-qualified defined contribution retirement plan under which eligible employees may defer their eligible compensation, subject to the limits imposed by the U.S. Internal Revenue Code, and the Company may, in its discretion, make a matching contribution of 100% on the first 3% of employee contributions and 50% on the employee contributions from 3% to 5%.

Prior

Elements of Our Compensation Programs for Named Executive Officers
The goal of our compensation plans and programs is to deliver appropriate, fiscally responsible compensation to named executive officers that focuses their resignations, both Dr. Noimanefforts on delivering results against short- and Mr. Rector were engaged as consultantslong-term objectives, provides sustained value to stockholders and did not participate in any retirement plansencourages the taking of responsible, appropriate and balanced risks. Accordingly, we have designed our compensation programs to include the Company.

following components:

Pay Mix
The value of these benefits is included above in the “All Other Compensation” column of the summaryCompensation Committee believes that compensation table.

Equity Compensation

All of the stock options held byfor our named executive officers must be a mix of variable compensation (both short- and long-term) and fixed compensation (base salary) in order to reinforce our executives’ responsibility to balance short- and long-term performance while maintaining focus on delivering value for our stockholders. As such, our programs offer opportunity for higher compensation for successful performance and lower compensation in the absence of success.

34

Base Salary
Base salaries for our named executive officers provide a fixed rate of pay and serve as the basis for calculating targets in certain variable pay programs. Starting salaries and subsequent increases are determined based on the following factors:

performance, experience, expected future contribution and ability to deliver value to stockholders;

analysis of internal pay relationships; and

market conditions and competitive positioning.
Annual Bonus
Our variable pay plan is designed to focus our named executive officers on annual goals and objectives that were granted under the 2013 Plan and outstanding immediately priorare established in order to contribute to the Transaction were assumed by the Companyshort- and converted into stock options to purchase shareslong-term success of our common stock,business. The Compensation Committee reviews and approves each plan year’s targets and performance metrics to ensure that they are challenging and commensurate with the number of sharesour short- and exercise price of such stock options converted to give effectlong-term business plan. Actual payments made are calculated based on performance in relation to the TransactionCompensation Committee approved goals.
Equity Grants
The Compensation Committee maintains that equity awards must align the interests of our named executive officers with those of our stockholders through rewarding exceptional corporate performance, stockholder returns and to our reverse stock split. Eachensuring that decisions made in the short-term solidify a strong future for us. As such, converted stock option will otherwise continue to be subjectawards granted pursuant to the same terms and conditions as were applicable2018 Equity Incentive Plan are an essential component of our total compensation strategy. The equity pool of awards available to the related Eloxx stock option immediately priorgrant to the Transaction.

Inducement Grants Made to Mr. Ward

Pursuant to his employment agreement, described above, on December 26, 2017, Mr. Ward received the following inducement awards pursuant to an inducement planall employees (including our named executive officers) in any given year is approved by our board of directors: 22,427 stock options and 22,427 restricted stock units awards, both of which will become earned and will vest upon the date that marks the first successful completion of aPhase-2B study with respect to any indication, subject to Mr. Ward’s continued service with us through such date; and 640,785 stock options and 640,785 restricted stock units awards, both of which will vestone-third on the first anniversary of the date of grant, andone-twelfth at the end of each quarter thereafter,the prior year by the Compensation Committee, subject to Mr. Ward’s continued service through the applicable vesting dates. Mr. Ward’s time-basedoverall maximum amount of shares of our stock available under the 2018 Equity Incentive Plan. Equity awards may also be accelerated upontake the achievementform of, certain Company performance milestones. Theamong others, stock options, granted to Mr. Ward have an exercise price equal to $8.00, which was the closing price of our commonrestricted stock on the date of grant.

units or performance stock units.

35

DIRECTOR COMPENSATION

The following table sets forth information concerning the compensation awarded to, earned by or paid ournon-employee directors during fiscal year 2018.
NameFees
Earned
or Paid
in Cash
($)
Stock Awards
($)
Option Awards
($)(1)(2)
All
Other
Compensation
($)
Total
($)
Tomer Kariv47,500(3)930,800978,300
Ran Nussbaum57,500(3)930,800988,300
Gadi Veinrib47,500930,800978,300
Zafrira Avnur, Ph.D.57,500(4)930,800988,300
Martijn Kleijwegt62,500(5)930,800993,300
Steven D. Rubin57,500930,800988,300
Sylvia Noiman, Ph.D.40,0003,290,122(6)4,220,922(6)7,551,044
Jasbir Seehra Ph.D.55,000930,800985,800
(1)
Amounts reflect the aggregate grant date fair value of option awards granted during the relevant fiscal year calculated in place starting asaccordance with FASB ASC Topic 718. Assumptions used in the calculation of these amounts are included in Note 11 to our audited financial statements included in our Annual Report on Form 10-K for the year ended December 31, 2017.

Name  Fees
Earned
or Paid in
Cash
($)
   Stock
Awards
($)
   Option
Awards
($) (2)
   Non-Equity
Incentive
Plan
Compensation
($)
   Nonqualified
Deferred
Compensation
Earnings
($)
   All
Other
Compensation
($)
   Total
($)
 

Tomer Kariv(1)

  $—      —      —      —      —      —     $—   

Ran Nussbaum (1)

  $—      —      —      —      —      —     $—   

Gadi Veinrib (1)

  $—      —      —      —      —      —     $—   

Zafrira Avnur, Ph.D. (1)

  $—      —      —      —      —      —     $—   

Martijn Kleijwegt (1)

  $—      —      —      —      —     —     $—   

Steven D. Rubin (3)

  $—      —      236,326    —      —      —     $236,326 

The following table sets forth information concerning2018. These amounts do not reflect the compensation awarded to, earnedactual economic value that may be realized by or paid ournon-employee directors who served as a director for partthe named executive officer upon the vesting of the fiscal year 2017, butrestricted stock unit or the sale of the common stock such restricted stock unit. The grant date fair value was not adjusted to take into account any estimated forfeitures. These awards had a grant date fair value of  $23.27 per share.

(2)
In June 2018, each non-employee director received an option award grant of 40,000 shares upon shareholder approval of the 2018 Incentive Equity Plan. The option awards vest over a two-year period from the date of grant.
(3)
Payments were no longer serving as of December 31, 2017.

Name Fees
Earned
or Paid in
Cash
($)
  Stock
Awards
($)
  Option
Awards
($) (2)
  Non-Equity
Incentive
Plan
Compensation
($)
  Nonqualified
Deferred
Compensation
Earnings
($)
  All
Other
Compensation
($)
  Total
($)
 

Dr. Robert A. Heft, Ph.D. (1) (4)

 $60,000   —     —     —     —     —    $60,000 

John Braca (5)

 $—     —     117,405   —     —     —    $117,405 

Dr. Phillip Frost (5)

 $—     —     36,982   —     —     —    $36,982 

Dr. Vaungh Smider (6)

 $—     —     —     —     —     —     —   

(1)Messrs. Kariv, Nussbaum, Veinrib, Kleijwegt and Drs. Heft and Avnur, each of whom served on the board of directors of Eloxx Limited prior to the Transaction, were appointed to serve on our Board on December 19, 2017. We did not pay any compensation, or make any equity awards ornon-equity incentive plan awards, to any of thesenon-employee members of our Board, in 2017. Mr. Braca, Dr. Frost and Dr. Smider each resigned from service on our Board on December 19, 2017. Dr. Heft resigned from service on our board of directors and as Chairman of our Board on December 26, 2017.
(2)Represents a grant of stock options made to Messrs. Rubin and Braca and Dr. Frost pursuant to the Amended and Restated Senesco Technologies, Inc. 2008 Incentive Compensation Plan in 2017, which each director elected to receive in lieu of cash fees, as described below. Each amount reflects the aggregate grant date fair value of the option award computed in accordance with FASB Topic ASC 718. Assumptions used in the calculation of these amounts are included in Notes 2 and 10 to the audited financial statements included in our Annual Report on Form10-K for the year ended June 30, 2017. The grant date fair value was not adjusted to take into account any estimated forfeitures.
(3)As of December 31, 2017, Mr. Rubin held a total of 59,120 stock options.
(4)As of December 31, 2017, Dr. Heft held a total of 340,415 stock options granted to him prior to the Transaction pursuant to the Eloxx Limited Employee Share Ownership and Option Plan (2013), which stock options were assumed by the Company in connection with the Transaction and converted to stock options to purchase shares of our common stock, as described above.
(5)As of December 31, 2017, Mr. Braca and Dr. Frost held a total of 36,958 and 15,887 stock options, respectively.
(6)As of December 31, 2017 Dr. Smider held a total of 1,266 and 711 stock options and warrants, respectively.

Priordirected to the Transaction, Messrs. RubinPontifax Funds as to which Mr. Kariv and BracaMr. Nussbaum may be deemed to share voting power and Dr. Frost were entitled to receive the following amounts of cash compensation, paidinvestment control in quarterly incrementstheir capacity as consideration for their service on the Board of Sevion during each fiscal year:

Annual (Base) Retainer

  $10,000 

Per Scheduled Board Meeting Fee

  $1,500(1) 

Per Committee Meeting Fee

  $750(2) 

Additional Annual Retainer:

  

Chairman of the Board of Directors

  $5,000 

Audit Committee Chair

  $3,500 

Compensation Committee Chair

  $3,500 

Nominating and Corporate Governance Committee Chair

  $1,500 

Non-Chair Committee Member Additional Retainer (All Committees)

  $1,000 

Maximum Per Diem for All Meetings

  $2,000 

(1)$750 for telephonic meetings (less than 30 minutes: $375).
(2)$375 for telephonic meetings.

However, thenon-employee directors could elect to receive, in lieumanaging partners of the above cash retainergeneral partners of the Pontifax Funds.

(4)
Payment was made to Global Health Science Fund which is a portfolio company of Quark Venture Inc. where Dr. Avnur serves as Chief Scientific Officer.
(5)
Payments were directed to Life Science Partners V as to which Mr. Kleijwegt may be deemed to share voting power and meeting fees, either (i)investment control in his capacity as managing partner of LSP V Management B.V.
(6)
Dr. Noiman resigned as the Company’s Chief Executive Officer on December 26, 2017. In June 2018, upon stockholder approval of the 2018 Incentive Equity Plan, and in accordance with an agreement with the Company, Dr. Noiman received a grant of 141,389 restricted stock units, or RSUs, covering that numberwhich vested immediately, and options to purchase 141,389 shares of common stock of the Company, in conjunction with her service as Chief Executive Officer. In addition, Dr. Noiman received options to purchase 40,000 shares havingof common stock of the Company for services as a fair market value ondirector. The option awards vest over a two-year period from the date of grant. These awards had a grant date equalfair value of  $23.27 per share.
The following sets forth the cash and equity compensation to such cash awardbe paid to our non-employee directors, in the year beginning immediately following the 2019 Annual Meeting, for service on our Board or (ii) a numberCommittees thereof.
36

Cash Compensation
Annual Fee
($)
DescriptionChairMember
Board of Directors40,000
Audit Committee15,0007,500
Compensation Committee10,0007,500
Nominating and Corporate Governance Committee10,0007,500
Strategic Finance Committee10,0007,500
Equity Compensation
Each non-employee director will receive an equity grant of 40,000 stock options equalupon initial election to twice the numberBoard and annual equity grants of RSU’s that would have been received,20,000 stock options upon each re-election to the Board. The equity will be granted upon election or re-election at each annual meeting, with an exercise price per share equal to the fair market value of our common stock on the option grant date.

In 2017, each of Messrs. Rubin and Braca and Dr. Frost elected to receive stock options in lieu of cash. Accordingly, the directors received stock options to purchase shares of our common stock with the exercise price per share equal to the closing price of our common stock on the option grant date. The grant date value of such equity awards is reflected in the table above. Each stock option award had a maximum term of 10 years subject to earlier termination 3 months following cessation of board service and was fully vestedprice on the grant date. The awards were made pursuantequity will vest as to 50% of the Amended and Restated Senesco Technologies, Inc. 2008 Incentive Compensation Plan, orstock options on the 2008 Plan, which we adopted in December 2008 to forfirst anniversary of the grant date and the remainder in twelve (12) monthly installments thereafter (an aggregate of stock options, stock grants and stock purchase rights to certain designated employees and certain other persons performing services for the Company, as designated by the Board. We do not intend to make grants under the 2008 Plan following the effectiveness of the 2018 Plan.

two-year vesting).

37

EQUITY COMPENSATION PLAN INFORMATION

The following table provides certain information with respect to all of our equity compensation plans in effect as of December 31, 2017.

Plan Category

  Number of
securities to be
issued upon
exercise of
outstanding
options,
warrants
and rights
(a)
  Weighted-average
exercise price of
outstanding
options,
warrants and
rights
(b)
   Number of
securities
remaining
available for
issuance
under equity
compensation
plans
(excluding
securities
reflected in
column (a))
(c)
 

Equity compensation plans approved by security holders:

   2,552,449  $4.11    252,995(1) 

Equity compensation plans not approved by security holders

   1,143,261(2)  $6.31    —   
  

 

 

    

 

 

 

Total

   3,965,710     252,995 
  

 

 

    

 

 

 

(1)On January 1 of each calendar year beginning with the calendar year 2015, the share reserve will automatically increase by 5% of the fully-diluted equity outstanding on the immediately preceding December 31, up to an annual maximum of 75,000 shares of common stock, provided that the aggregate number of shares subject to outstanding awards will not exceed 25% of the fully-diluted equity outstanding. An additional 75,000 shares were added on January 1, 2018.
(2)Represents warrants to purchase 480,049 shares of common stock with a weighted-average exercise price of $3.97 per share, along with 640,785 time-vesting options to purchase our common stock with an exercise price equal to $8.00 per share and 22,427 performance-based options to purchase our common stock with an exercise price equal to $8.00 per share.

Plan CategoryNumber of
Securities to be
Issued Upon
Exercise of
Outstanding
Options, Warrants
and Rights
(a)
Weighted-
average
Exercise Price of
Outstanding
Options,
Warrants and
Rights
(b)
Number of
Securities
Remaining
Available for
Issuance under
Equity
Compensation
Plans
(Excluding
Securities
Reflected in
Column (a))
(c)
Equity compensation plans approved by security holders2,634,03814.623,519,438(1)
Equity compensation plans not approved by security holders1,529,070(2)
Total4,163,1083,519,438

(1)
On January 1 of each calendar year the share reserve will automatically increase by 5% of the fully-diluted equity outstanding on the immediately preceding December 31, up to an annual maximum of 10,000,000 shares of common stock available for future issuance. An additional 1,793,006 shares were added on January 1, 2019.
(2)
Represents warrants to purchase 347,241 shares of common stock with a weighted-average exercise price of  $3.77 per share, along with time-based restricted stock units for 427,190 shares of common stock, 22,427 performance-based restricted stock units, 709,785 time-vesting options to purchase our common stock with an exercise price equal to $7.87 per share and 22,427 performance-based options to purchase our common stock with an exercise price equal to $8.00 per share.
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TRANSACTIONS WITH RELATED PERSONS

Related Person Transactions Policy and Procedures

We adopted a related person transaction policy that sets forth our procedures for the identification, review, consideration and approval or ratification of related person transactions.

For purposes of our policy only, a related person transaction is a transaction, arrangement or relationship, or any series of similar transactions, arrangements or relationships, in which we and any related person are, were or will be participantshave a material interest in which the amount involves exceeds $120,000.the lesser of $120,000 or one percent of the average of our assets for the last two completed fiscal years. Transactions involving compensation for services provided to us as an employee or director are not covered by this policy. A related person is any executive officer, director or beneficial owner of more than 5% of any class of our voting securities, including any of their immediate family members and any entity owned or controlled by such persons.

Under the policy, if a transaction has been identified as a related person transaction, including any transaction that was not a related person transaction when originally consummated or any transaction that was not initially identified as a related person transaction prior to consummation, our management must present information regarding the related person transaction to our Audit Committee, or, if Audit Committee approval would be inappropriate, to another independent body of our Board, for review, consideration and approval or ratification. The presentation must include a description of, among other things, the material facts, the interests, direct and indirect, of the related persons, the benefits to us of the transaction and whether the transaction is on terms that are comparable to the terms available to or from, as the case may be, an unrelated third party or to or from employees generally. Under the policy, we collect information that we deem reasonably necessary from each director, executive officer and, to the extent feasible, significant stockholder to enable us to identify any existing or potential related person transactions and to effectuate the terms of the policy.

In considering related person transactions, the Audit Committee, or other independent body of our Board, takes into account the relevant available facts and circumstances including, but not limited to (a) the risks, costs and benefits to us, (b) the impact on a director’s independence in the event the related person is a director, immediate family member of a director or an entity with which a director is affiliated, (c) the availability of other sources for comparable services or products and (d) the terms available to or from, as the case may be, unrelated third parties or to or from employees generally.

The policy requires that, in determining whether to approve, ratify or reject a related person transaction, our Audit Committee, or other independent body of our Board, must consider, in light of known circumstances, whether the transaction is in, or is not inconsistent with, our best interests and those of our stockholders, as our Audit Committee, or other independent body of our Board, determines in the good faith exercise of its discretion.

Certain Related Person Transactions

Reverse Merger

Except as described below, there have been no transactions since January 1, 2018 in which we are a participant and Subscription Agreements

On May 31, 2017, Sevion, Sevion Sub Ltd., an Israeli company (“Acquisition Sub”), which was a wholly-owned subsidiarythe amount involved exceeds the lesser of  Sevion, and Private Eloxx entered into an Agreement (the “Transaction Agreement”), pursuant to which Acquisition Sub merged with and into Private Eloxx, with Private Eloxx becoming the surviving corporation and a wholly-owned subsidiary of Sevion (the “Transaction”).

On December 19, 2017, the Transaction was consummated. Upon consummation$120,000 or one percent of the Transaction (the “Closing”), Sevion adoptedaverage of our assets for the business planlast two completed fiscal years, and in which any of Private Eloxxour directors, executive officers or holders of more than 5% of our common stock, or any members of their immediate family, had or will have a direct or indirect material interest, other than compensation arrangements which are described under “Executive Compensation” and discontinued the pursuit“Director Compensation.”

Policy for Approval of Sevion’s business plan pre-Closing. In connectionRelated Person Transactions
Pursuant its charter, our Audit Committee is responsible for reviewing on an ongoing basis and approving all “related party transactions” in accordance with the Transaction, Sevion acquired allpolicy described herein. Under the Company policy, our Audit Committee is responsible for reviewing and approving related person transactions. In the course of its review and approval of related person transactions, our Audit Committee will consider the relevant facts and circumstances to decide whether to approve such transactions, including whether the transaction is on terms no less favorable than terms generally available to an unaffiliated third
39

party under the same or similar circumstances and the extent of the outstanding capital stock of Private Eloxx in exchange for the issuance of an aggregate 20,316,656 shares of Sevion’s common stock, par value $0.01 per share (the “Common Stock”), after giving effect to a 1-for-20 reverse split effected immediately prior to the Transaction (the “Reverse Merger”). As a result of the Transaction, Private Eloxx became a wholly-

owned subsidiary of Sevion. While Sevion was the legal acquirerrelated person’s interest in the transaction, Private Eloxx was deemedtransaction. Related person transactions must be approved or ratified by the accounting acquirer. Immediately after giving effect toAudit Committee based on full information about the Transaction, on December 19, 2017, Sevion changed its name to Eloxx Pharmaceuticals, Inc.

The Transaction Agreement required that between the signing of the Transaction Agreementproposed transaction and the closing of the Transaction, both Sevion and Private Eloxx engage in various fundraising transactions with investors, including entities affiliated with their respective Board of Directors, in amounts that exceeded in the aggregate $30 million as previously disclosed.

related person’s interest.

Director and Officer Indemnification

Prior to the completion of the Transaction, we

We entered into indemnification agreements with each of our directors and executive officers. These agreements require us to indemnify these individuals and, in certain cases, affiliates of such individuals, to the fullest extent permissible under Delaware law against liabilities that may arise by reason of their service to us or at our direction, and to advance expenses incurred as a result of any proceeding against them as to which they could be indemnified. Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, we have been informed that in the opinion of the SEC such indemnification is against public policy and is therefore unenforceable.

Policy

When are stockholder proposals and director nominations due for Approvalnext year’s Annual Meeting?
To be considered for inclusion in next year’s proxy materials, you must submit your proposal, in writing, by December 7, 2019 to our Corporate Secretary c/o Eloxx Pharmaceuticals, Inc. at 950 Winter Street, Waltham, Massachusetts 02451, and you must comply with all applicable requirements of Related Person Transactions

Pursuant its charter, our Audit Committee is responsible for reviewing on an ongoing basis and approving all “related party transactions” in accordance with the policy described herein. Under the Company policy, our Audit Committee is responsible for reviewing and approving related person transactions. In the course of its review and approval of related person transactions, our Audit Committee will consider the relevant facts and circumstances to decide whether to approve such transactions, including whether the transaction is on terms no less favorable than terms generally available to an unaffiliated third partyRule 14a-8 promulgated under the sameExchange Act.

Pursuant to our By-laws, if you wish to bring a proposal before the stockholders or similar circumstancesnominate a director at the 2020 Annual Meeting of Stockholders, but you are not requesting that your proposal or nomination be included in next year’s proxy materials, you must notify our Corporate Secretary, in writing, not later than the close of business on February 15, 2020 nor earlier than the close of business on January 16, 2020. You are also advised to review our By-laws, which contain additional requirements about advance notice of stockholder proposals and director nominations.
40

DELIVERY OF DOCUMENTS TO STOCKHOLDERS SHARING AN ADDRESS
To the extent we deliver a paper copy of the related person’s interest inproxy materials to stockholders, the transaction. Related person transactions must be approved or ratified by the Audit Committee based on full information about the proposed transaction and the related person’s interest.

HOUSEHOLDING OF PROXY MATERIALS

The SEC has adopted rules that permit companies and intermediaries (e.g., brokers)allow us to satisfy the delivery requirements for Annual Meetingdeliver a single copy of proxy materials with respect to any household at which two or more stockholders sharingreside, if we believe the stockholders are members of the same family.

We will promptly deliver, upon oral or written request, a separate copy of the proxy materials to any stockholder residing at the same address by delivering a single setas another stockholder and currently receiving only one copy of Annual Meetingthe proxy materials addressed to those stockholders. This process, which is commonly referred to as “householding,” potentially means extra convenience for stockholders and cost savings for companies.

This year, a number of brokers with account holders who are our stockholders will be “householding” our proxy materials. A single set of Annual Meeting materials will be delivered to multiple stockholders sharing an address unless contrary instructions have been received from the affected stockholders. Once you have received notice from your broker that they will be “householding” communications to your address, “householding” will continue until you are notified otherwise or until you revoke your consent. If, at any time, you no longer wish to participate in “householding” and would preferwishes to receive a separate set of Annual Meeting materials, please notify your brokerhis or her own copy. Requests should be directed to our Corporate Secretary by phone at (781) 577-5300 or by mail to Eloxx Pharmaceuticals, Inc. Direct your written request to Eloxx Pharmaceuticals, Inc., Attn: Corporate Secretary,at 950 Winter Street, Waltham, Massachusetts 02451. Stockholders whoAny stockholders residing at the same address and currently receive multiplereceiving separate copies of the Annual Meetingproxy materials who wish to receive only one copy of the proxy materials for the household may request that only a single copy be sent to the household. Requests should be directed to our Corporate Secretary by phone at their addresses and would like(781) 577-5300 or by mail to request “householding” of their communications should contact their brokers.

Eloxx Pharmaceuticals, Inc. at 950 Winter Street, Waltham, Massachusetts 02451.

OTHER MATTERS

The

Upon written request addressed to our Corporate Secretary at Eloxx Pharmaceuticals, Inc. at 950 Winter Street Waltham, Massachusetts 02451 from any person solicited herein, we will provide, at no cost, a paper copy of our fiscal 2018 Annual Report on Form 10-K filed with the SEC.
Our Board of Directors knowsdoes not know of noany matter to be brought before the Annual Meeting other than the matters that will be presented for consideration atset forth in the Notice of Annual Meeting of Stockholders and matters incident to the conduct of the Annual Meeting. If any other matters arematter should properly broughtcome before the Annual Meeting, it is the intention of the persons named in the accompanying proxy card will have discretionary authority to vote on such mattersall proxies with respect thereto in accordance with their best judgment.

By Order of the Board of Directors,

Gregory Weaver

[MISSING IMAGE: sg_neil-belloff.jpg]
Neil S. Belloff
Corporate Secretary

April 16, 2018

A copy5, 2019

41

[MISSING IMAGE: tv517860_proxycard-p1.jpg]
ELOXX PHARMACEUTICALS, INC.950 WINTER STREETWALTHAM, MA 02451SCAN TOVIEW MATERIALS & VOTEVOTE BY INTERNET - www.proxyvote.com or scan the QR Barcode aboveUse the Internet to transmit your voting instructions and for electronic delivery of information up until 11:59 p.m. Eastern Time on May 28, 2019. Have your proxy card in hand when you access the web site and follow the instructions to obtain your records and to create an electronic voting instruction form.ELECTRONIC DELIVERY OF FUTURE PROXY MATERIALSIf you would like to reduce the costs incurred by our company in mailing proxy materials, you can consent to receiving all future proxy statements, proxy cards and annual reports electronically via e-mail or the Internet. To sign up for electronic delivery, please follow the instructions above to vote using the Internet and, when prompted, indicate that you agree to receive or access proxy materials electronically in future years.VOTE BY PHONE - 1-800-690-6903Use any touch-tone telephone to transmit your voting instructions up until 11:59 p.m. Eastern Time on May 28, 2019. Have your proxy card in hand when you call and then follow the instructions.VOTE BY MAILMark, sign and date your proxy card and return it in the postage-paid envelope we have provided or return it to Vote Processing, c/o Broadridge, 51 Mercedes Way,Edgewood, NY 11717.TO VOTE, MARK BLOCKS BELOW IN BLUE OR BLACK INK AS FOLLOWS:E63681-P20204 KEEP THIS PORTION FOR YOUR RECORDS THIS PROXY CARD IS VALID ONLY WHEN SIGNED AND DATED.ELOXX PHARMACEUTICALS, INC. ForAll WithholdAll For AllExcept The Board of Directors recommends you vote FOR the following proposals: To withhold authority to vote for any individual nominee(s), mark "For All Except" and write the number(s) of the nominee(s) on the line below. 1.Election of Directors 01) Robert E. Ward02) Zafrira Avnur03) Tomer Kariv04) Martijn Kleijwegt05) Silvia Noiman 06) Ran Nussbaum07) Steven Rubin08) Jasbir Seehra09) Gadi VeinribFor Against Abstain 2.Ratification of the selection of Deloitte & Touche LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2019. 3.Advisory approval of the compensation of our named executive officers, as disclosed in the Proxy Statement. 1 Year 2 Years 3 Years Abstain4.Advisory indication of the preferred frequency of advisory votes on the compensation of our named executive officers. NOTE: The shares represented by this proxy, when properly executed, will be voted in the manner directed herein by the undersigned stockholder(s) and, inthe discretion of the proxies, upon such other business as may properly come before the meeting. If no direction is made, this proxy will be voted FOR thenominees for the Board of Directors listed in Proposal 1, FOR Proposals 2 and 3, and 1 Year with respect to Proposal 4.Please indicate if you plan to attend this meeting.YesNoPlease sign exactly as your name(s) appear(s) hereon. When signing as attorney, executor, administrator, or other fiduciary, please give full title as such. Joint owners should each sign personally. All holders must sign. If a corporation or partnership, please sign in full corporate or partnership name by authorized officer. Signature [PLEASE SIGN WITHIN BOX]DateSignature (Joint Owners)Date

[MISSING IMAGE: tv517860_proxycard-p2.jpg]
Important Notice Regarding the Availability of Proxy Materials for the Annual Meeting:The Notice of Annual Meeting and Proxy Statement and Annual Report on Form10-K for the fiscal year ended December 31, 2017, as filed with the Securities and Exchange Commission, is are available without charge upon written request to: Eloxx Pharmaceuticals, Inc., Attn: Corporate Secretary, 950 Winter Street Waltham, Massachusetts 02451.

LOGO

ANNUAL MEETING OFat www.proxyvote.com.E63682-P20204 ELOXX PHARMACEUTICALS, INC.

Date:

Wednesday, May 16, 2018

Time:

2:00 p.m. Tel Aviv Time

Place:

The Ritz Carlton, Herzliya, 4 Hashunit Street, Herzliya, 4655504 Israel

Please make your marks like this:      Use dark black pencil or pen only

The Board of Directors Recommends a VoteFOReach of the director nominees listed in proposal 1 andFOR proposal 2.

1:

To elect the nine nominees for director named below to hold office until the 2019 Annual Meeting of Stockholders.

ForAgainstAbstain
(01) Robert E. Ward
(02) Tomer Kariv
(03) Ran Nussbaum
(04) Silvia Noiman, Ph.D.
(05) Gadi Veinrib
(06) Zafrira Avnur, Ph.D.
(07) Martijn Kleijwegt
(08) Steven D. Rubin
(09) Jasbir Seehra, Ph.D.

ForAgainstAbstain

2:

To ratify the selection by the Audit Committee of the Board of Directors of Kost Forer Gabbay & Kasierer (a member of Ernst & Young Global) as the independent registered public accounting firm of the Company for its fiscal year ending December 31, 2018.

To attend the meeting and vote your sharesin person, please mark this box.
Authorized Signatures - This section must becompleted for your Instructions to be executed.

Please Sign HerePlease Date Above

Please Sign HerePlease Date Above

Please sign exactly as your name(s) appears on your stock certificate. If held in joint tenancy, all persons should sign. Trustees, administrators, etc., should include title and authority. Corporations should provide full name of corporation and title of authorized officer signing the proxy.

LOGO   Please separate carefully at the perforation and return just this portion in the envelope provided.  LOGO

LOGO

AnnualINC.Annual Meeting of Eloxx Pharmaceuticals, Inc.

to be held on Wednesday, May 16, 2018

for Holders as of March 19, 2018

ThisStockholdersMay 29, 2019 1:00 PMThis proxy is being solicited on behalf ofby the Board of Directors

VOTE BY:
              LOGO     INTERNET            LOGO     TELEPHONE

Go To

Call

www.proxypush.com/elox

      866-430-8292

Cast your vote online 24 hours a day/7 days a week.

OR

Use any touch-tone telephone toll-free 24 hours a day/7 days a week.

Have your Proxy Card/Voting Instructions Form ready.

LOGOMAIL


Have your Proxy Card/Voting Instruction Form ready.

Follow the simple recorded instructions.

View Meeting Documents.

          OR

Mark, sign and date your Proxy Card/Voting Instruction Form.

Detach your Proxy Card/Voting Instruction Form.

Return your Proxy Card/Voting Instruction Form in the

postage-paid envelope provided.

TheDirectorsThe undersigned hereby appoints Robert E. Ward and Gregory Weaver, and each or either of them, as the true and lawful attorneys of the undersigned, with full power of substitution and revocation, and authorizes them, and each of them, to vote all the shares of common stock of Eloxx Pharmaceuticals, Inc. which the undersigned is entitled to vote at said meeting and any adjournmentadjournments thereof upon the matters specified and upon such other matters as may be properly brought before the meeting or any adjournmentadjournments thereof, conferring authority upon such true and lawful attorneys to vote in their discretion on such other matters as may properly come before the meeting and revoking any proxy heretofore given.

THE SHARES REPRESENTED BY THIS PROXY WILL BE VOTED AS DIRECTED OR, IF NO DIRECTION IS GIVEN, SHARES WILL BE VOTED FOR THE ELECTION OF THE DIRECTORS IN ITEM 1 AND FOR THE PROPOSAL IN ITEM 2. THE PROXIES WILL VOTE IN THEIR DISCRETION ON ANY OTHER BUSINESS AS MAY PROPERLY COME BEFORE THE MEETING AND ANY ADJOURNMENT THEREOF.

All votes mustgiven.This proxy, when properly executed, will be received by 5:00 P.M., Tel Aviv Time, May 15, 2018.

PROXY TABULATOR FOR

ELOXX PHARMACEUTICALS, INC.

c/o MEDIANT COMMUNICATIONS

P.O. BOX 8016

CARY, NC 27512-9903

EVENT #

CLIENT #

voted in the manner directed herein. If no such direction is made, this proxy will be voted in accordance with the Board of Directors' recommendations.Please mark, sign and return this proxy card promptly using the enclosed reply envelope.Continued and to be signed on reverse side